Organophosphorous pesticide breakdown products in house dust and children's urine

Lesliam Quirós-Alcalá, Asa Bradman, Kimberly Smith, Gayanga Weerasekera, Martins Odetokun, Dana Boyd Barr, Marcia Nishioka, Rosemary Castorina, Alan E. Hubbard, Mark Nicas, S. Katharine Hammond, Thomas E. McKone, Brenda Eskenazi

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Human exposure to preformed dialkylphosphates (DAPs) in food or the environment may affect the reliability of DAP urinary metabolites as biomarkers of organophosphate (OP) pesticide exposure. We conducted a study to investigate the presence of DAPs in indoor residential environments and their association with children's urinary DAP levels. We collected dust samples from homes in farmworker and urban communities (40 homes total, n79 samples) and up to two urine samples from resident children ages 36 years. We measured six DAPs in all samples and eight DAP-devolving OP pesticides in a subset of dust samples (n54). DAPs were detected in dust with diethylphosphate (DEP) being the most frequently detected (60%); detection frequencies for other DAPs were 50%. DEP dust concentrations did not significantly differ between communities, nor were concentrations significantly correlated with concentrations of chlorpyrifos and diazinon, the most frequently detected diethyl-OP pesticides (Spearman ρ0.41 to 0.38, P>0.05). Detection of DEP, chlorpyrifos, or diazinon, was not associated with DEP and/or DEPdiethylthiophosphate detection in urine (Kappa coefficients0.33 to 0.16). Finally, estimated non-dietary ingestion intake from DEP in dust was found to be 5% of the dose calculated from DEP levels in urine, suggesting that ingestion of dust is not a significant source of DAPs in urine if they are excreted unchanged.

Original languageEnglish (US)
Pages (from-to)559-568
Number of pages10
JournalJournal of Exposure Science and Environmental Epidemiology
Issue number6
StatePublished - Nov 2012
Externally publishedYes


  • biomarkers
  • dialkylphosphates
  • dust
  • metabolites
  • organophosphates
  • urine

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health


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