Organometallic carbonyl clusters: A new class of contrast agents for photoacoustic cerebral vascular imaging

Kien Voon Kong, Lun De Liao, Zhiyong Lam, Nitish V Thakor, Weng Kee Leong, Malini Olivo

Research output: Contribution to journalArticle

Abstract

We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.

Original languageEnglish (US)
Pages (from-to)2601-2603
Number of pages3
JournalChemical Communications
Volume50
Issue number20
DOIs
StatePublished - Mar 11 2014

Fingerprint

Photoacoustic microscopy
Organometallic Compounds
Photoacoustic effect
Image enhancement
Organometallics
Single-walled carbon nanotubes (SWCN)
Contrast Media
Rats
Imaging techniques
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Organometallic carbonyl clusters : A new class of contrast agents for photoacoustic cerebral vascular imaging. / Kong, Kien Voon; Liao, Lun De; Lam, Zhiyong; Thakor, Nitish V; Leong, Weng Kee; Olivo, Malini.

In: Chemical Communications, Vol. 50, No. 20, 11.03.2014, p. 2601-2603.

Research output: Contribution to journalArticle

Kong, Kien Voon ; Liao, Lun De ; Lam, Zhiyong ; Thakor, Nitish V ; Leong, Weng Kee ; Olivo, Malini. / Organometallic carbonyl clusters : A new class of contrast agents for photoacoustic cerebral vascular imaging. In: Chemical Communications. 2014 ; Vol. 50, No. 20. pp. 2601-2603.
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