TY - JOUR
T1 - Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
AU - Colt, Joanne S.
AU - Rothman, Nathaniel
AU - Severson, Richard K.
AU - Hartge, Patricia
AU - Cerhan, James R.
AU - Chatterjee, Nilanjan
AU - Cozen, Wendy
AU - Morton, Lindsay M.
AU - De Roos, Anneclaire J.
AU - Davis, Scott
AU - Chanock, Stephen
AU - Wang, Sophia S.
PY - 2009/2/26
Y1 - 2009/2/26
N2 - Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute-Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and α-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate ß coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C-1615T) TT and IL4 (5′-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3′-UTR, Ex22+871A>G) AA, IL8(T-251A) TT, and IL10 (A-1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. (Blood. 2009;113:1899-1905)
AB - Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute-Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and α-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate ß coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C-1615T) TT and IL4 (5′-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3′-UTR, Ex22+871A>G) AA, IL8(T-251A) TT, and IL10 (A-1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. (Blood. 2009;113:1899-1905)
UR - http://www.scopus.com/inward/record.url?scp=61849090772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61849090772&partnerID=8YFLogxK
U2 - 10.1182/blood-2008-04-153858
DO - 10.1182/blood-2008-04-153858
M3 - Article
C2 - 19066394
AN - SCOPUS:61849090772
SN - 0006-4971
VL - 113
SP - 1899
EP - 1905
JO - Blood
JF - Blood
IS - 9
ER -