Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems

Sachie K. Ogawa, Jeremiah Y. Cohen, Dabin Hwang, Naoshige Uchida, Mitsuko Watabe-Uchida

Research output: Contribution to journalArticle

Abstract

Serotonin and dopamine are major neuromodulators. Here, we used a modified rabies virus to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR). We found that inputs to DR and MR serotonin neurons are spatially shifted in the forebrain, and MR serotonin neurons receive inputs from more medial structures. Then, we compared these data with inputs to dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). We found that DRserotonin neurons receive inputs from a remarkably similar set of areas as VTA dopamine neurons apart from the striatum, which preferentially targets dopamine neurons. Our results suggest three major inputstreams: a medial stream regulates MR serotonin neurons, an intermediate stream regulates DR serotonin and VTA dopamine neurons, and a lateral stream regulates SNc dopamine neurons. These results provide fundamental organizational principles of afferent control for serotonin and dopamine.

Original languageEnglish (US)
Pages (from-to)1105-1118
Number of pages14
JournalCell Reports
Volume8
Issue number4
DOIs
StatePublished - Aug 21 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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