Organization and regulation of proteins at synapses

Jee Hae Kim, Richard L Huganir

Research output: Contribution to journalArticle

Abstract

The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and coordinated molecular and cellular processes. The unveiling of various protein-protein interactions and their functional consequences at synapses have led to a greater understanding of the process of synapse formation and the modulation of synaptic transmission. Recent studies indicate that the major excitatory neurotransmitter receptors in the brain, the glutamate receptors, are associated with many different molecules that are involved in the formation of elaborate synaptic cytoskeletal networks and signal transduction cascades. These complex protein networks may play critical roles in the regulation of neurotransmitter receptor function and the efficacy of synaptic transmission.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume11
Issue number2
DOIs
StatePublished - Apr 1 1999
Externally publishedYes

Fingerprint

Synapses
Neurotransmitter Receptor
Synaptic Transmission
Proteins
Glutamate Receptors
Nervous System
Signal Transduction
Brain

ASJC Scopus subject areas

  • Cell Biology

Cite this

Organization and regulation of proteins at synapses. / Kim, Jee Hae; Huganir, Richard L.

In: Current Opinion in Cell Biology, Vol. 11, No. 2, 01.04.1999, p. 248-254.

Research output: Contribution to journalArticle

@article{566eae54e79b41129668e3cb3ee5412b,
title = "Organization and regulation of proteins at synapses",
abstract = "The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and coordinated molecular and cellular processes. The unveiling of various protein-protein interactions and their functional consequences at synapses have led to a greater understanding of the process of synapse formation and the modulation of synaptic transmission. Recent studies indicate that the major excitatory neurotransmitter receptors in the brain, the glutamate receptors, are associated with many different molecules that are involved in the formation of elaborate synaptic cytoskeletal networks and signal transduction cascades. These complex protein networks may play critical roles in the regulation of neurotransmitter receptor function and the efficacy of synaptic transmission.",
author = "Kim, {Jee Hae} and Huganir, {Richard L}",
year = "1999",
month = "4",
day = "1",
doi = "10.1016/S0955-0674(99)80033-7",
language = "English (US)",
volume = "11",
pages = "248--254",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Organization and regulation of proteins at synapses

AU - Kim, Jee Hae

AU - Huganir, Richard L

PY - 1999/4/1

Y1 - 1999/4/1

N2 - The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and coordinated molecular and cellular processes. The unveiling of various protein-protein interactions and their functional consequences at synapses have led to a greater understanding of the process of synapse formation and the modulation of synaptic transmission. Recent studies indicate that the major excitatory neurotransmitter receptors in the brain, the glutamate receptors, are associated with many different molecules that are involved in the formation of elaborate synaptic cytoskeletal networks and signal transduction cascades. These complex protein networks may play critical roles in the regulation of neurotransmitter receptor function and the efficacy of synaptic transmission.

AB - The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and coordinated molecular and cellular processes. The unveiling of various protein-protein interactions and their functional consequences at synapses have led to a greater understanding of the process of synapse formation and the modulation of synaptic transmission. Recent studies indicate that the major excitatory neurotransmitter receptors in the brain, the glutamate receptors, are associated with many different molecules that are involved in the formation of elaborate synaptic cytoskeletal networks and signal transduction cascades. These complex protein networks may play critical roles in the regulation of neurotransmitter receptor function and the efficacy of synaptic transmission.

UR - http://www.scopus.com/inward/record.url?scp=0032915393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032915393&partnerID=8YFLogxK

U2 - 10.1016/S0955-0674(99)80033-7

DO - 10.1016/S0955-0674(99)80033-7

M3 - Article

C2 - 10209161

AN - SCOPUS:0032915393

VL - 11

SP - 248

EP - 254

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 2

ER -