Abstract
Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular microbiologic methods for a number of diseases, insights provided into the role of bacteria in chronic rhinosinusitis have yet to be fully understood to the point of impacting clinical diagnosis and management. As culture-independent techniques continue to evolve and become more refined, it is likely that a better understanding will emerge of how the microbiome influences chronic rhinosinusitis pathogenesis and response to therapy.
Original language | English (US) |
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Journal | Otolaryngologic Clinics of North America |
DOIs | |
State | Accepted/In press - 2017 |
Keywords
- Chronic rhinosinusitis
- Metagenome
- Microbiota
- RNA, Ribosomal, 16S
- Sequence analysis, DNA
ASJC Scopus subject areas
- Otorhinolaryngology