Organ preservation trials for laryngeal cancer

Jill Gilbert, Arlene A. Forastiere

Research output: Contribution to journalReview articlepeer-review


Organ-preservation strategies include definitive radiation therapy alone, induction chemotherapy followed by radiotherapy, and concurrent chemoradiotherapy. Over the past decade, induction chemotherapy followed by radiotherapy has been the standard for the nonsurgical management of advanced laryngeal cancer. Over this same period, however, other nonsurgical strategies have been under evaluation. These approaches include radiotherapy with concurrent chemotherapy to take advantage of the radiosensitizing properties of most cytotoxic drugs with activity against squamous cell cancer, altered fractionation radiotherapy, and the incorporation of molecularly targeted therapeutics into multimodality treatment.

Original languageEnglish (US)
Pages (from-to)1035-1054
Number of pages20
JournalOtolaryngologic Clinics of North America
Issue number5
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Otorhinolaryngology


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