TY - JOUR
T1 - Organ preservation trials for laryngeal cancer
AU - Gilbert, Jill
AU - Forastiere, Arlene A.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Organ-preservation strategies include definitive radiation therapy alone, induction chemotherapy followed by radiotherapy, and concurrent chemoradiotherapy. Over the past decade, induction chemotherapy followed by radiotherapy has been the standard for the nonsurgical management of advanced laryngeal cancer. Over this same period, however, other nonsurgical strategies have been under evaluation. These approaches include radiotherapy with concurrent chemotherapy to take advantage of the radiosensitizing properties of most cytotoxic drugs with activity against squamous cell cancer, altered fractionation radiotherapy, and the incorporation of molecularly targeted therapeutics into multimodality treatment.
AB - Organ-preservation strategies include definitive radiation therapy alone, induction chemotherapy followed by radiotherapy, and concurrent chemoradiotherapy. Over the past decade, induction chemotherapy followed by radiotherapy has been the standard for the nonsurgical management of advanced laryngeal cancer. Over this same period, however, other nonsurgical strategies have been under evaluation. These approaches include radiotherapy with concurrent chemotherapy to take advantage of the radiosensitizing properties of most cytotoxic drugs with activity against squamous cell cancer, altered fractionation radiotherapy, and the incorporation of molecularly targeted therapeutics into multimodality treatment.
UR - http://www.scopus.com/inward/record.url?scp=0036813036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036813036&partnerID=8YFLogxK
U2 - 10.1016/S0030-6665(02)00035-X
DO - 10.1016/S0030-6665(02)00035-X
M3 - Review article
C2 - 12587246
AN - SCOPUS:0036813036
SN - 0030-6665
VL - 35
SP - 1035
EP - 1054
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 5
ER -