Organ preservation review: History of organ preservation

Andrew M. Cameron, Jose F.Barandiaran Cornejo

Research output: Contribution to journalReview article

Abstract

Purpose of review To summarize the history of organ preservation and place into this context the current trends in preservation. Recent findings Multiple large retrospective studies have analyzed cold preservation solutions in an attempt to determine superiority with largely negative results. Experimental and some clinical studies have examined machine perfusion of procured grafts, in both hypothermic and normothermic contexts with variable, but promising, results. Lastly, there are experimental efforts to evaluate mesenchymal stem cell therapy on rehabilitation of marginal donor organs. Summary New trends in organ preservation may soon translate into more efficient use of the limited donor pool.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalCurrent opinion in organ transplantation
Volume20
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • cold storage
  • ex-vivo machine perfusion
  • mesenchymal stem cells
  • organ preservation
  • preservation solution

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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