TY - JOUR
T1 - Organ Preservation for Cancer of the Larynx
T2 - Current Indications and Future Directions
AU - Gilbert, Jill
AU - Forastiere, Arlene A.
PY - 2004/4
Y1 - 2004/4
N2 - The optimal regimen for organ preservation for laryngeal cancer remains an area of active investigation. Multiple organ-preservation strategies have been explored, including radiation therapy alone, induction chemotherapy followed by radiation therapy, and concomitant chemoradiotherapy. Until recently, induction chemotherapy followed by radiation therapy was the standard of care for organ preservation in the United States. However, recent data from the Intergroup Trial, R 91-11 has placed concomitant chemoradiotherapy in the forefront as the standard of care for organ preservation. Newer strategies are being investigated and include the use of induction chemotherapy before concomitant chemoradiotherapy and the integration of novel biological agents. It remains to be seen whether such interventions can improve on the excellent locoregional control shown in the landmark Intergroup trial.
AB - The optimal regimen for organ preservation for laryngeal cancer remains an area of active investigation. Multiple organ-preservation strategies have been explored, including radiation therapy alone, induction chemotherapy followed by radiation therapy, and concomitant chemoradiotherapy. Until recently, induction chemotherapy followed by radiation therapy was the standard of care for organ preservation in the United States. However, recent data from the Intergroup Trial, R 91-11 has placed concomitant chemoradiotherapy in the forefront as the standard of care for organ preservation. Newer strategies are being investigated and include the use of induction chemotherapy before concomitant chemoradiotherapy and the integration of novel biological agents. It remains to be seen whether such interventions can improve on the excellent locoregional control shown in the landmark Intergroup trial.
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U2 - 10.1053/j.semradonc.2003.12.003
DO - 10.1053/j.semradonc.2003.12.003
M3 - Article
C2 - 15095262
AN - SCOPUS:2342570395
VL - 14
SP - 167
EP - 177
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
SN - 1053-4296
IS - 2
ER -