Organ failure: Central nervous system

Neeraj Naval, Satish Chandolu, Marek Mirski

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Central nervous system (CNS) failure represents a spectrum of disease ranging from mild neurological impairment that may have motor, sensory, visual, speech, cognitive manifestations, or a combination thereof, to comatose states and brain death. This article summarizes the common causes of CNS failure and analyzes the role of clinical, radiological, laboratory, and other ancillary testing in establishing the underlying diagnosis and assessing severity of CNS failure in each condition; we also comment on various treatment options for each of the causes of CNS failure.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalSeminars in Respiratory and Critical Care Medicine
Issue number5
StatePublished - Oct 19 2011


  • Central nervous system failure
  • anoxic brain injury
  • encephalopathy
  • intracerebral hemorrhage
  • ischemic stroke
  • status epilepticus
  • subarachnoid hemorrhage
  • traumatic brain injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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