Order from disorder: Self-organization in mammalian hair patterning

Yanshu Wang, Tudor Badea, Jeremy Nathans

Research output: Contribution to journalArticle

Abstract

Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)-/- mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs. By analyzing the orientation of developing hair follicles, we observed that the nearly parallel arrangement of wild-type (WT) hairs arises from fields of imperfectly aligned follicles, and that the Fz6-/- hair patterns arise from fields of grossly misoriented or randomly oriented follicles. Despite their large size, both mutant and WT hair follicles display a remarkable and unexpected plasticity, reorienting on a time scale of days in what seems to be a self-organized refinement process. The essential features of this process can be studied with a simple cellular automata model in which a local consensus "rule" acts iteratively to bias each hair's orientation in favor of the average orientation of its neighbors. These experiments define two systems for hair orientation: a global orienting system that acts early in development and is Fz6-depandent, and a local self-organizing system that acts later and is Fz6 independent.

Original languageEnglish (US)
Pages (from-to)19800-19805
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number52
DOIs
StatePublished - Dec 26 2006

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Hair
Hair Follicle
Feathers

Keywords

  • Frizzled
  • Hair development
  • Hair follicle
  • Planar cell polarity

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Order from disorder : Self-organization in mammalian hair patterning. / Wang, Yanshu; Badea, Tudor; Nathans, Jeremy.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 52, 26.12.2006, p. 19800-19805.

Research output: Contribution to journalArticle

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