TY - JOUR
T1 - Orbital necrobiotic xanthogranuloma associated with systemic IgG4 disease
AU - Singh, Kamaljeet
AU - Rajan, Kda
AU - Eberhart, Charles
PY - 2010/10
Y1 - 2010/10
N2 - Purpose: The authors describe 2 cases of orbital xanthogranulomatous disease associated with an increase in IgG4-positive plasma cells, and also examine IgG4 in other types of orbital inflammation. Methods: Immunohistochemistry for total IgG and IgG4 was performed in 18 cases of orbital inflammation, including chronic dacryoadenitis (n10), necrobiotic xanthogranuloma (n2), xanthogranuloma (n1), idiopathic orbital inflammation/pseudotumor (n4), and fungal infection (n1). Results: One patient presenting with necrobiotic xanthogranuloma had signs of systemic IgG4 disease. His orbital lesion showed an elevated number of IgG4 positive plasma cells (55%). An orbital xanthogranulomatous lesion in a second patient lacking systemic symptoms also contained a high percentage of IgG4-positive plasma cells (80%). Only 1 case of chronic dacryoadenitis contained prominent IgG4-positive plasma cells (mean 17/hpf). Conclusions: IgG4-positive plasma cells are relatively rare in nonsclerosing orbital inflammatory lesions. However, systemic disease IgG4 can be associated with necrobiotic xanthogranuloma of the orbit.
AB - Purpose: The authors describe 2 cases of orbital xanthogranulomatous disease associated with an increase in IgG4-positive plasma cells, and also examine IgG4 in other types of orbital inflammation. Methods: Immunohistochemistry for total IgG and IgG4 was performed in 18 cases of orbital inflammation, including chronic dacryoadenitis (n10), necrobiotic xanthogranuloma (n2), xanthogranuloma (n1), idiopathic orbital inflammation/pseudotumor (n4), and fungal infection (n1). Results: One patient presenting with necrobiotic xanthogranuloma had signs of systemic IgG4 disease. His orbital lesion showed an elevated number of IgG4 positive plasma cells (55%). An orbital xanthogranulomatous lesion in a second patient lacking systemic symptoms also contained a high percentage of IgG4-positive plasma cells (80%). Only 1 case of chronic dacryoadenitis contained prominent IgG4-positive plasma cells (mean 17/hpf). Conclusions: IgG4-positive plasma cells are relatively rare in nonsclerosing orbital inflammatory lesions. However, systemic disease IgG4 can be associated with necrobiotic xanthogranuloma of the orbit.
KW - Dacryoadenitis
KW - IGG
KW - IGG4
KW - Lymphocytic sclerosing pancreatitis
KW - Orbital xanthogranuloma
UR - http://www.scopus.com/inward/record.url?scp=77956800078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956800078&partnerID=8YFLogxK
U2 - 10.3109/09273948.2010.490629
DO - 10.3109/09273948.2010.490629
M3 - Article
C2 - 20716008
AN - SCOPUS:77956800078
VL - 18
SP - 373
EP - 378
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
IS - 5
ER -