Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family

Gary H. Posner, Michael H. Parker, John Northrop, Jeffrey S. Elias, Poonsakdi Ploypradith, Suji Xie, Theresa A. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

In only three chemical operations, natural trioxane lactone artemisinin (1) was converted into a series of C-10 carbon-substituted 10- deoxoartemisinin compounds 4-9. The three steps involved lactone reduction, replacement of the anomeric lactol OH by F using diethylaminosulfur trifluoride, and finally boron trifluoride-promoted substitution of F by aryl, heteroaryl, and acetylide nucleophiles. All of these C-10 nonacetal, chemically robust, enantiomerically pure compounds 4-9 have high antimalarial potencies in vitro against Plasmodium falciparum malaria parasites, and furans 5a and 5b and pyrrole 7a are antimalarially potent also in vivo even when administered to rodents orally.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalJournal of medicinal chemistry
Volume42
Issue number2
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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