ORAL VERSUS INTRAMUSCULAR VITAMIN A IN THE TREATMENT OF XEROPHTHALMIA

Alfred Sommer, Ignatius Tarwotio, Muhilal, Edi Djunaedi, John Glover

Research output: Contribution to journalArticlepeer-review

Abstract

In a controlled trial 69 children with corneal xerophthalmia were given 200 000 IU oil-miscible vitamin A by mouth and a matched group of 45 children were given 100 000 IU water-miscible vitamin A intramuscularly. Both groups received an additional oral dose the next day. There was no detectable difference in the clinical response to the two regimens, even when analysis was limited to patients with concomitant diarrhœa or protein-energy malnutrition. Although serum-vitamin-A levels were significantly higher after parenteral than oral therapy, holoretinol-binding-protein levels were not. Oral administration of vitamin A is not only more practical but appears to be just as effective as parenteral administration in the treatment of severe xerophthalmia.

Original languageEnglish (US)
Pages (from-to)557-559
Number of pages3
JournalThe Lancet
Volume315
Issue number8168
DOIs
StatePublished - Mar 15 1980

ASJC Scopus subject areas

  • Medicine(all)

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