@article{6522112a972745e5af1f9ec1921b9501,
title = "ORAL VERSUS INTRAMUSCULAR VITAMIN A IN THE TREATMENT OF XEROPHTHALMIA",
abstract = "In a controlled trial 69 children with corneal xerophthalmia were given 200 000 IU oil-miscible vitamin A by mouth and a matched group of 45 children were given 100 000 IU water-miscible vitamin A intramuscularly. Both groups received an additional oral dose the next day. There was no detectable difference in the clinical response to the two regimens, even when analysis was limited to patients with concomitant diarrh{\oe}a or protein-energy malnutrition. Although serum-vitamin-A levels were significantly higher after parenteral than oral therapy, holoretinol-binding-protein levels were not. Oral administration of vitamin A is not only more practical but appears to be just as effective as parenteral administration in the treatment of severe xerophthalmia.",
author = "Alfred Sommer and Ignatius Tarwotio and Muhilal and Edi Djunaedi and John Glover",
note = "Funding Information: medical attention. Many have systemic illnesses and pro- tein-energy malnutrition (PEM). Severe PEM, in par- ticular, interferes with storage and handling of vitamin A and may lead to early relapse after either parenteral or oral treatment. We did not encounter any evidence of toxicity except for occasional asymptomatic papilloedema. Although oral therapy consisted of two doses of 200 000 IU oil- miscible vitamin A given on successive days, a third stores even 1-2 weeks further later, and would or probably reduce the improve risk of clini-liver delay cal relapse. We thank Dr Susan T. Pettiss for her encouragment and support. The Nutritional Blindness Prevention Project is supported by the Office of Nutrition, United States Agency for International Develop- ment. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "1980",
month = mar,
day = "15",
doi = "10.1016/S0140-6736(80)91053-3",
language = "English (US)",
volume = "315",
pages = "557--559",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8168",
}