Oral tetracycline therapy in cholera

C. K. Wallace, C. C.J. Carpenter, P. P. Mitra, R. B. Sack, S. K. Khanra, A. S. Werner, T. P. Duffy, A. Oleinick, G. W. Lewis

Research output: Contribution to journalArticlepeer-review


The present study represents 3 groups of severely ill male cholera patients, who upon admission were similar in all respects except weight. 11 control patients received only routine intravenous replacement therapy and no antibiotics. The other 2 groups both received 2 grammes of tetracycline; 17 patients received 500 mg. every 6 hours for 4 doses and 14 received 250 mg. every 6 hours for 8 doses. The results clearly demonstrate that 2 grammes of oral tetracycline given in equally divided doses for either 1 or 2 days was effective in reducing the amount and duration of the diarrhoea as well as in reducing the percentage of positive V. cholerae cultures. This small dosage of tetracycline was not effective in establishing an irreversible vibriosterilizing effect, and several treated patients continued to excrete vibrios longer than the control patients.

Original languageEnglish (US)
Pages (from-to)621-627
Number of pages7
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number6
StatePublished - Nov 1965

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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