Oral tetracycline therapy in cholera

C. K. Wallace; C. C.J. Carpenter; P. P. Mitra; R. B. Sack; S. K. Khanra; A. S. Werner; T. P. Duffy; A. Oleinick; G. W. Lewis

doi:10.1016/0035-9203(65)90091-X

Oral tetracycline therapy in cholera

C. K. Wallace, C. C.J. Carpenter, P. P. Mitra, R. B. Sack, S. K. Khanra, A. S. Werner, T. P. Duffy, A. Oleinick, G. W. Lewis

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The present study represents 3 groups of severely ill male cholera patients, who upon admission were similar in all respects except weight. 11 control patients received only routine intravenous replacement therapy and no antibiotics. The other 2 groups both received 2 grammes of tetracycline; 17 patients received 500 mg. every 6 hours for 4 doses and 14 received 250 mg. every 6 hours for 8 doses. The results clearly demonstrate that 2 grammes of oral tetracycline given in equally divided doses for either 1 or 2 days was effective in reducing the amount and duration of the diarrhoea as well as in reducing the percentage of positive V. cholerae cultures. This small dosage of tetracycline was not effective in establishing an irreversible vibriosterilizing effect, and several treated patients continued to excrete vibrios longer than the control patients.

Original language	English (US)
Pages (from-to)	621-627
Number of pages	7
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	59
Issue number	6
DOIs	https://doi.org/10.1016/0035-9203(65)90091-X
State	Published - Nov 1965
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/0035-9203(65)90091-X

Cite this

@article{2eaf8a833ead466b96c9680f3246e480,

title = "Oral tetracycline therapy in cholera",

abstract = "The present study represents 3 groups of severely ill male cholera patients, who upon admission were similar in all respects except weight. 11 control patients received only routine intravenous replacement therapy and no antibiotics. The other 2 groups both received 2 grammes of tetracycline; 17 patients received 500 mg. every 6 hours for 4 doses and 14 received 250 mg. every 6 hours for 8 doses. The results clearly demonstrate that 2 grammes of oral tetracycline given in equally divided doses for either 1 or 2 days was effective in reducing the amount and duration of the diarrhoea as well as in reducing the percentage of positive V. cholerae cultures. This small dosage of tetracycline was not effective in establishing an irreversible vibriosterilizing effect, and several treated patients continued to excrete vibrios longer than the control patients.",

author = "Wallace, {C. K.} and Carpenter, {C. C.J.} and Mitra, {P. P.} and Sack, {R. B.} and Khanra, {S. K.} and Werner, {A. S.} and Duffy, {T. P.} and A. Oleinick and Lewis, {G. W.}",

note = "Funding Information: This investigation was supported by United States Public Heakh Service Research Grant No. H.26.6114 from the National Institutes of Health. The authors would like to express their sincere appreciation to Dr. R. N. Chaudhuri, Director of the Calcutta School of Tropical Medicine, and his staff and to Dr. P.M. Manji, Superintendent, and Dr. A. Das, Clinical Director of the Infectious Diseases Hospital and their staff for their continued interest, advice and support of this study. We especially thank Dr. D. Barua, Professor of Bacteriology, School of Tropical Medicine, under whose direction the haemagglutination studies and phage typing were performed. We are indebted to Dr. J Roy of the Indian Statistical Institute for his advice and review of our statistical data.",

year = "1965",

month = nov,

doi = "10.1016/0035-9203(65)90091-X",

language = "English (US)",

volume = "59",

pages = "621--627",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Oral tetracycline therapy in cholera

AU - Wallace, C. K.

AU - Carpenter, C. C.J.

AU - Mitra, P. P.

AU - Sack, R. B.

AU - Khanra, S. K.

AU - Werner, A. S.

AU - Duffy, T. P.

AU - Oleinick, A.

AU - Lewis, G. W.

N1 - Funding Information: This investigation was supported by United States Public Heakh Service Research Grant No. H.26.6114 from the National Institutes of Health. The authors would like to express their sincere appreciation to Dr. R. N. Chaudhuri, Director of the Calcutta School of Tropical Medicine, and his staff and to Dr. P.M. Manji, Superintendent, and Dr. A. Das, Clinical Director of the Infectious Diseases Hospital and their staff for their continued interest, advice and support of this study. We especially thank Dr. D. Barua, Professor of Bacteriology, School of Tropical Medicine, under whose direction the haemagglutination studies and phage typing were performed. We are indebted to Dr. J Roy of the Indian Statistical Institute for his advice and review of our statistical data.

PY - 1965/11

Y1 - 1965/11

N2 - The present study represents 3 groups of severely ill male cholera patients, who upon admission were similar in all respects except weight. 11 control patients received only routine intravenous replacement therapy and no antibiotics. The other 2 groups both received 2 grammes of tetracycline; 17 patients received 500 mg. every 6 hours for 4 doses and 14 received 250 mg. every 6 hours for 8 doses. The results clearly demonstrate that 2 grammes of oral tetracycline given in equally divided doses for either 1 or 2 days was effective in reducing the amount and duration of the diarrhoea as well as in reducing the percentage of positive V. cholerae cultures. This small dosage of tetracycline was not effective in establishing an irreversible vibriosterilizing effect, and several treated patients continued to excrete vibrios longer than the control patients.

AB - The present study represents 3 groups of severely ill male cholera patients, who upon admission were similar in all respects except weight. 11 control patients received only routine intravenous replacement therapy and no antibiotics. The other 2 groups both received 2 grammes of tetracycline; 17 patients received 500 mg. every 6 hours for 4 doses and 14 received 250 mg. every 6 hours for 8 doses. The results clearly demonstrate that 2 grammes of oral tetracycline given in equally divided doses for either 1 or 2 days was effective in reducing the amount and duration of the diarrhoea as well as in reducing the percentage of positive V. cholerae cultures. This small dosage of tetracycline was not effective in establishing an irreversible vibriosterilizing effect, and several treated patients continued to excrete vibrios longer than the control patients.

UR - http://www.scopus.com/inward/record.url?scp=50549218305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50549218305&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(65)90091-X

DO - 10.1016/0035-9203(65)90091-X

M3 - Article

AN - SCOPUS:50549218305

SN - 0035-9203

VL - 59

SP - 621

EP - 627

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 6

ER -

Oral tetracycline therapy in cholera

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this