Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa

Research output: Contribution to journalArticle

Abstract

Sensory evaluation of food involves endogenous opioid mechanisms. Bulimics typically limit their food choices to low-fat "safe foods" and intermittently lose control and binge on high-fat "risk foods". The aim of this study was to determine whether the oral sensory effects of a fat versus a non-fat milk product (i.e., traditional versus non-fat half-and-half) resulted in different subjective and hormonal responses in bulimic women (n=10) compared with healthy women (n=11). Naltrexone (50. mg PO) or placebo was administered 1. h before, and blood sampling began 30. min prior to and 29. min after, a 3. min portion controlled modified sham-feeding trial. Following an overnight fast, three morning trials (fat, naltrexone; fat, placebo; and non-fat, placebo) were administered in a random double-blind fashion separated by at least 3. days. Overall, there were no differences between Fat and Non-Fat trials. Hunger ratings (p

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalPhysiology and Behavior
Volume99
Issue number5
DOIs
StatePublished - Apr 2010

Fingerprint

Bulimia Nervosa
Fats
Head
Food
Naltrexone
Placebos
Hunger
Opioid Analgesics
Milk

Keywords

  • Bulimia
  • Eating disorders
  • Hedonics
  • Insulin
  • Modified sham-feeding
  • Opiates
  • Taste

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology

Cite this

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abstract = "Sensory evaluation of food involves endogenous opioid mechanisms. Bulimics typically limit their food choices to low-fat {"}safe foods{"} and intermittently lose control and binge on high-fat {"}risk foods{"}. The aim of this study was to determine whether the oral sensory effects of a fat versus a non-fat milk product (i.e., traditional versus non-fat half-and-half) resulted in different subjective and hormonal responses in bulimic women (n=10) compared with healthy women (n=11). Naltrexone (50. mg PO) or placebo was administered 1. h before, and blood sampling began 30. min prior to and 29. min after, a 3. min portion controlled modified sham-feeding trial. Following an overnight fast, three morning trials (fat, naltrexone; fat, placebo; and non-fat, placebo) were administered in a random double-blind fashion separated by at least 3. days. Overall, there were no differences between Fat and Non-Fat trials. Hunger ratings (p",
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AU - Guarda, Angela S

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