Oral self-administration of methohexital in baboons

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Abstract

Oral self-administration of methohexital was generated in baboons that were food-restricted but not water-deprived. Stable intake of an 8% ethanol solution (two baboons) or water (two baboons) was first established in 3-h-sessions. Increasing concentrations of methohexital (0.005-10 mg/ml) then were substituted with a return to the ethanol or water baseline condition between methohexital conditions. For one baboon in the ethanol baseline condition, drinking was initially suppressed by methohexital substitution, but increased under a food-induced drinking procedure. For all baboons, an inverted U-shaped function generally described the relation between methohexital concentration and volume consumed. Anesthetization was observed at concentrations of 1.6 mg/ml and above. In two-bottle choice tests, three baboons generally drank greater volumes of methohexital than water at concentrations of 0.8 mg/ml and above. After a methohexital-free period of 1-3 months methohexital self-administration was readily reestablished.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalPsychopharmacology
Volume79
Issue number2-3
DOIs
StatePublished - Feb 1 1983

Keywords

  • Baboons
  • Drinking
  • Ethanol
  • Methohexital
  • Sedative-hypnotics
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology

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