Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature

Mark A. Scheper, Nikolaos G. Nikitakis, Rui Fernandes, Christopher Gocke, Robert A. Ord, John J. Sauk

Research output: Contribution to journalArticle

Abstract

Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases.

Original languageEnglish (US)
Pages (from-to)198-206
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume100
Issue number2
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

HIV
CD45 Antigens
Desmin
Keratins
Rare Diseases
Jaw
Human Herpesvirus 4
Non-Hodgkin's Lymphoma
Immunoglobulin A
Immunoglobulin M
Mouth
Actins
Lymphoma
Membrane Proteins
B-Lymphocytes
Immunoglobulin G
Lymphocytes
Phenotype
Light
Plasmablastic Lymphoma

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Oral plasmablastic lymphoma in an HIV-negative patient : A case report and review of the literature. / Scheper, Mark A.; Nikitakis, Nikolaos G.; Fernandes, Rui; Gocke, Christopher; Ord, Robert A.; Sauk, John J.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 100, No. 2, 08.2005, p. 198-206.

Research output: Contribution to journalArticle

Scheper, Mark A. ; Nikitakis, Nikolaos G. ; Fernandes, Rui ; Gocke, Christopher ; Ord, Robert A. ; Sauk, John J. / Oral plasmablastic lymphoma in an HIV-negative patient : A case report and review of the literature. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2005 ; Vol. 100, No. 2. pp. 198-206.
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