Oral iodine supplementation does not reduce neutralizing antibody responses to oral poliovirus vaccine

R. E. Taffs, J. C. Enterline, K. Rusmil, Muhilal, S. S. Suwardi, D. Rustama, Djatnika, C. Cobra, R. D. Semba, N. Cohen, D. M. Asher

Research output: Contribution to journalArticle

Abstract

Iodine deficiency is a major cause of impaired mental development, goitre, and cretinism in many parts of the world. Because existing immunization programmes can be used to deliver oral iodized oil (OIO) to infants at risk, it was important to know whether OIO could adversely affect the antibody response to vaccines, such as trivalent oral poliovirus vaccine (OPV). A randomized, double-blind, placebo-controlled clinical trial was conducted in Subang, West Java, Indonesia, in which 617 eight-week-old infants received either OIO or a placebo (poppy-seed oil) during a routine visit for their first dose of OPV as part of the Expanded Programme on immunization (EPI). The infants received two boosters of OPV at 4-week intervals after the first dose, and were followed up when 6 months old. Neutralizing antibody titres to poliovirus serotypes 1, 2, and 3 were compared in serum samples that were taken from 478 of these infants just before the first dose of OPV and at 6 months. It was found that oral iodized oil did not reduce the antibody responses to any of the three serotypes of OPV. These results indicate that oral iodine may safely be delivered to infants at the same time as oral poliovirus vaccine according to current EPI immunization schedules.

Original languageEnglish (US)
Pages (from-to)484-491
Number of pages8
JournalBulletin of the World Health Organization
Volume77
Issue number6
StatePublished - Jul 14 1999

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Oral iodine supplementation does not reduce neutralizing antibody responses to oral poliovirus vaccine'. Together they form a unique fingerprint.

  • Cite this

    Taffs, R. E., Enterline, J. C., Rusmil, K., Muhilal, Suwardi, S. S., Rustama, D., Djatnika, Cobra, C., Semba, R. D., Cohen, N., & Asher, D. M. (1999). Oral iodine supplementation does not reduce neutralizing antibody responses to oral poliovirus vaccine. Bulletin of the World Health Organization, 77(6), 484-491.