Oral ibuprofen and tetracycline for the treatment of acne vulgaris

Reynold C. Wong, Sewon Kang, Jan L. Heezen, John J. Voorhees, Charles N. Ellis

Research output: Contribution to journalArticlepeer-review

Abstract

A prospective evaluation of the efficacy and safety of oral ibuprofen and tetracycline hydrochloride was conducted for 8 weeks in patients with moderately severe acne. Sixty-eight patients were randomly assigned in a double-blind fashion to one of four regimens: (1) one 600 mg ibuprofen tablet plus one 250 mg tetracycline capsule four times daily; (2) one 600 mg ibuprofen tablet plus one placebo capsule four times daily; (3) one 250 mg tetracycline capsule plus one placebo tablet four times daily; and (4) one placebo tablet and one placebo capsule four times daily. Sixty patients completed the 8-week study. The mean percent improvement in the groups treated with ibuprofen and tetracycline (56% ± 5 SE), ibuprofen alone (26% ±13 SE), or tetracycline alone (26% ± 9 SE) was statistically significant. However, only the combination of ibuprofen and tetracycline therapy had an effect statistically better than the placebo response (16% ± 11 SE). Adverse effects were transient and were similar in all four groups.

Original languageEnglish (US)
Pages (from-to)1076-1081
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume11
Issue number6
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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