Oral Human Papillomavirus Infection in Adults Is Associated with Sexual Behavior and HIV Serostatus

Aimee R. Kreimer, Anthony J. Alberg, Richard Daniel, Patti E. Gravitt, Rapheal Viscidi, Elizabeth S. Garrett, Keerti V. Shah, Maura L. Gillison

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence and risk factors for oral human papillomavirus (HPV) infection are unknown, despite evidence for an etiological role for HPV in oral cancers. Oral samples from human immunodeficiency virus (HIV)-seronegative (n = 396) and HIV-seropositive (n = 190) adults were tested for HPV DNA. High-risk HPV infections were present in 2.1% of tonsil and 6.3% of oral-rinse specimens. The prevalence of oral high-risk HPV infection was greater in HIV-seropositive individuals (13.7% vs. 4.5%; P < .001). In multiple logistic regression, odds of oral HPV infection increased with age, male sex, and herpes simplex virus (HSV)-2 seropositivity in HIV-seronegative individuals and with CD4 cell count <200 cells/mL, HSV-2 seropositivity, oral mucosal abnormalities, and >1 oral sex partner during the previous year (odds ratio, 12.8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection.

Original languageEnglish (US)
Pages (from-to)686-698
Number of pages13
JournalJournal of Infectious Diseases
Volume189
Issue number4
DOIs
StatePublished - Feb 15 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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