Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

G. D. Batty, Q. Li, R. Huxley, S. Zoungas, B. A. Taylor, B. Neal, B. de Galan, M. Woodward, S. B. Harrap, S. Colagiuri, A. Patel, J. Chalmers

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalEuropean Psychiatry
Volume28
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Cognitive decline
  • Cohort study
  • Dementia
  • Oral disease

ASJC Scopus subject areas

  • Psychiatry and Mental health

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