Abstract
The incidence of disease caused by Mycobacterium tuberculosis (including drug-resistant strains) and M. avium complex (MAC) is increasing. Hypersensitivity reactions to antimycobacterial agents are relatively uncommon, but when they occur they may result in cessation of therapeutic medications. We report our experience with rapid oral desensitization to ethambutol and rifampin in a group of 10 patients with mycobacterial disease who had experienced cutaneous hypersensitivity reactions to these drugs. An adaptation of the rapid oral desensitization protocol for penicillin was used, with the dosing intervals increased to account for the different kinetics of these drugs. Adverse reactions were few and easily treated without necessitating cessation of therapy. We conclude that oral desensitization to rifampin and ethambutol by our protocol is safe and effective, allowing these patients to proceed with an optimal antimycobacterial regimen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 815-817 |
| Number of pages | 3 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 149 |
| Issue number | 3 I |
| DOIs | |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
Cite this
Oral desensitization to rifampin and ethambutol in mycobacterial disease. / Matz, Jonathan; Borish, Larry C.; Routes, John M.; Rosenwasser, Lanny J.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 149, No. 3 I, 01.01.1994, p. 815-817.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral desensitization to rifampin and ethambutol in mycobacterial disease
AU - Matz, Jonathan
AU - Borish, Larry C.
AU - Routes, John M.
AU - Rosenwasser, Lanny J.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The incidence of disease caused by Mycobacterium tuberculosis (including drug-resistant strains) and M. avium complex (MAC) is increasing. Hypersensitivity reactions to antimycobacterial agents are relatively uncommon, but when they occur they may result in cessation of therapeutic medications. We report our experience with rapid oral desensitization to ethambutol and rifampin in a group of 10 patients with mycobacterial disease who had experienced cutaneous hypersensitivity reactions to these drugs. An adaptation of the rapid oral desensitization protocol for penicillin was used, with the dosing intervals increased to account for the different kinetics of these drugs. Adverse reactions were few and easily treated without necessitating cessation of therapy. We conclude that oral desensitization to rifampin and ethambutol by our protocol is safe and effective, allowing these patients to proceed with an optimal antimycobacterial regimen.
AB - The incidence of disease caused by Mycobacterium tuberculosis (including drug-resistant strains) and M. avium complex (MAC) is increasing. Hypersensitivity reactions to antimycobacterial agents are relatively uncommon, but when they occur they may result in cessation of therapeutic medications. We report our experience with rapid oral desensitization to ethambutol and rifampin in a group of 10 patients with mycobacterial disease who had experienced cutaneous hypersensitivity reactions to these drugs. An adaptation of the rapid oral desensitization protocol for penicillin was used, with the dosing intervals increased to account for the different kinetics of these drugs. Adverse reactions were few and easily treated without necessitating cessation of therapy. We conclude that oral desensitization to rifampin and ethambutol by our protocol is safe and effective, allowing these patients to proceed with an optimal antimycobacterial regimen.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028212309&partnerID=8YFLogxK
U2 - 10.1164/ajrccm.149.3.8118654
DO - 10.1164/ajrccm.149.3.8118654
M3 - Article
C2 - 8118654
AN - SCOPUS:0028212309
VL - 149
SP - 815
EP - 817
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 3 I
ER -