Oral clefts, maternal smoking, and TGFA

A meta-analysis of gene-environment interaction

Joanna S. Zeiger, Terri L Beaty, Kung Yee Liang

Research output: Contribution to journalArticle

Abstract

Objective: A meta-analysis was performed to examine the association among maternal cigarette smoking, infant genotype at the Taq1 site in the transforming growth factor α (TGFA) locus, and risk of nonsyndromic oral clefts, both cleft palate (CP) and cleft lip with or without cleft palate (CL/P). Design: Five published case-control studies were included in the meta-analyis. Pooled Mantel-Haenszel odds ratios (OR) and 95% confidence intervals (CIs) were computed. Gene-environment interaction was also assessed by using the pooled data in a case-only analysis and polytomous logistic regression. Results: Among nonsmoking mothers, there was no evidence of any increased risk for CP if the infant carried the TGFA Taq1 C2 allele. If the mother reported smoking, however, there was an overall increased risk for CP if the infant carried the C2 allele (OR smokers = 1.95; 95% CI = 1.22 to 3.10). TGFA genotype did not increase risk to CL/P, regardless of maternal smoking status. Polytomous logistic regression revealed a significant overall smoking effect for CL/P (OR = 1.64, 95% Cl = 1.33 to 2.02) and CP (OR = 1.42, 95% CI = 1.06 to 1.90). Conclusions: While maternal smoking was a consistent risk factor for both CL/P and CP across all studies, the suggestive evidence for gene-environment interaction between the infant's genotype at the Taq1 marker in TGFA and maternal smoking was limited to CP. Furthermore, evidence for such gene-environment interaction was strongest in a case-control study drawn from a birth defect registry where infants with non-cleft defects served as controls.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalCleft Palate-Craniofacial Journal
Volume42
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

Gene-Environment Interaction
Cleft Palate
Transforming Growth Factors
Meta-Analysis
Smoking
Mothers
Odds Ratio
Genotype
Confidence Intervals
Case-Control Studies
Logistic Models
Alleles
Cleft Lip
Registries

Keywords

  • CL/P
  • CP
  • Epidemiology
  • Meta-analysis
  • Oral clefts
  • TGFA

ASJC Scopus subject areas

  • Surgery
  • Dentistry(all)

Cite this

Oral clefts, maternal smoking, and TGFA : A meta-analysis of gene-environment interaction. / Zeiger, Joanna S.; Beaty, Terri L; Liang, Kung Yee.

In: Cleft Palate-Craniofacial Journal, Vol. 42, No. 1, 01.2005, p. 58-63.

Research output: Contribution to journalArticle

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abstract = "Objective: A meta-analysis was performed to examine the association among maternal cigarette smoking, infant genotype at the Taq1 site in the transforming growth factor α (TGFA) locus, and risk of nonsyndromic oral clefts, both cleft palate (CP) and cleft lip with or without cleft palate (CL/P). Design: Five published case-control studies were included in the meta-analyis. Pooled Mantel-Haenszel odds ratios (OR) and 95{\%} confidence intervals (CIs) were computed. Gene-environment interaction was also assessed by using the pooled data in a case-only analysis and polytomous logistic regression. Results: Among nonsmoking mothers, there was no evidence of any increased risk for CP if the infant carried the TGFA Taq1 C2 allele. If the mother reported smoking, however, there was an overall increased risk for CP if the infant carried the C2 allele (OR smokers = 1.95; 95{\%} CI = 1.22 to 3.10). TGFA genotype did not increase risk to CL/P, regardless of maternal smoking status. Polytomous logistic regression revealed a significant overall smoking effect for CL/P (OR = 1.64, 95{\%} Cl = 1.33 to 2.02) and CP (OR = 1.42, 95{\%} CI = 1.06 to 1.90). Conclusions: While maternal smoking was a consistent risk factor for both CL/P and CP across all studies, the suggestive evidence for gene-environment interaction between the infant's genotype at the Taq1 marker in TGFA and maternal smoking was limited to CP. Furthermore, evidence for such gene-environment interaction was strongest in a case-control study drawn from a birth defect registry where infants with non-cleft defects served as controls.",
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