Abstract
Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.
Original language | English (US) |
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Pages (from-to) | 115-119 |
Number of pages | 5 |
Journal | Journal of pediatric gastroenterology and nutrition |
Volume | 53 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- age
- children
- choline
- intestinal failure
- percentile
- plasma
- requirement
- short gut
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Gastroenterology