Oral choline supplementation in children with intestinal failure

Anthony L. Guerrerio, Lynn Mattis, Kim G. Conner, Jenifer Hampsey, D. Mikis Stasinopoulos, Robert Dejong, Emad M. Boctor, Shelia Sheth, Ulrike M. Hamper, Ann O. Scheimann

Research output: Contribution to journalArticle

Abstract

Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume53
Issue number1
DOIs
StatePublished - Jul 1 2011

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Keywords

  • age
  • children
  • choline
  • intestinal failure
  • percentile
  • plasma
  • requirement
  • short gut

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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