Oral cholera vaccines containing B-subunit-killed whole cells and killed whole cells only. II. Field evaluation of cross-protection against other members of the Vibrionaceae family

John D. Clemens, Jeffrey R. Harris, Bradford A. Kay, J. Chakraborty, David Allen Sack, M. Ansaruzzaman, Rezaur Rahman, Bonita F. Stanton, M. U. Khan, M. R. Khan, Md Yunus, M. R. Rao, Ivan Čižnǎr, Ann Mari Svennerholm, Jan Holmgren

Research output: Contribution to journalArticle

Abstract

Because of demonstrable cross-reactivity of cellular antigens contained in B subunit-killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines with antigens of various non-cholera species of the family Vibrionaceae (NCV), the protection conferred by the vaccines against diarrhoea associated with NCV was evaluated during a randomized, double-blind field trial in Bangladesh. Children aged 2-15 years and women aged >15 years (62 285 in number) received three doses of BS-WC vaccine, WC-only vaccine, or a placebo consisting of Escherichia coli K12 strain (K12). During 1 year of follow-up, the incidence of treated episodes of diarrhoea associated with non-cholera vibrios known to be enteric pathogens (non-01 Vibrio cholerae, V. fluvialis, V. parahaemolyticus, V. mimicus) in the placebo group was low (1.9 cases per 10 000 recipients) and identical to that for the two vaccine groups combined. The incidence (per 10 000 recipients) of treated diarrhoeal episodes associated with Aeromonas species was considerably higher, but nearly identical in the three groups (26.1 cases for BS-WC, 26.0 cases for WC; 25.9 cases for K12). Pleisiomonas shigelloides was not isolated from any participant. It is concluded that NCV other than Aeromonas were rarely isolated from diarrhoeal patients in our study population and that killed oral vaccines which were effective against cholera exhibited no detectable cross-protection against diarrhoea associated with NCV organisms.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalVaccine
Volume7
Issue number2
DOIs
StatePublished - 1989

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Keywords

  • cholera
  • Cross-protection
  • Vibrio species

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Clemens, J. D., Harris, J. R., Kay, B. A., Chakraborty, J., Sack, D. A., Ansaruzzaman, M., Rahman, R., Stanton, B. F., Khan, M. U., Khan, M. R., Yunus, M., Rao, M. R., Čižnǎr, I., Svennerholm, A. M., & Holmgren, J. (1989). Oral cholera vaccines containing B-subunit-killed whole cells and killed whole cells only. II. Field evaluation of cross-protection against other members of the Vibrionaceae family. Vaccine, 7(2), 117-120. https://doi.org/10.1016/0264-410X(89)90048-0