TY - JOUR
T1 - Oral cavity and oropharyngeal squamous cell carcinoma genomics
AU - Tan, Marietta
AU - Myers, Jeffrey N.
AU - Agrawal, Nishant
PY - 2013/8
Y1 - 2013/8
N2 - Recent technological advances now permit the study of the entire cancer genome, which can elucidate complex pathway interactions that are not apparent at the level of single genes. In this review, the authors describe innovations that have allowed for whole-exome/genome analysis of genetic and epigenetic alterations and of changes in gene expression. Studies using next-generation sequencing, array comparative genomic hybridization, methylation arrays, and gene expression profiling are reviewed, with a particular focus on findings from recent whole-exome sequencing projects. A discussion of the implications of these data on treatment and future goals for cancer genomics is included.
AB - Recent technological advances now permit the study of the entire cancer genome, which can elucidate complex pathway interactions that are not apparent at the level of single genes. In this review, the authors describe innovations that have allowed for whole-exome/genome analysis of genetic and epigenetic alterations and of changes in gene expression. Studies using next-generation sequencing, array comparative genomic hybridization, methylation arrays, and gene expression profiling are reviewed, with a particular focus on findings from recent whole-exome sequencing projects. A discussion of the implications of these data on treatment and future goals for cancer genomics is included.
KW - Genomics
KW - Head and neck squamous cell carcinoma
KW - Oral cavity
KW - Oropharyngeal squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84881026430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881026430&partnerID=8YFLogxK
U2 - 10.1016/j.otc.2013.04.001
DO - 10.1016/j.otc.2013.04.001
M3 - Review article
C2 - 23910469
AN - SCOPUS:84881026430
SN - 0030-6665
VL - 46
SP - 545
EP - 566
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 4
ER -