Oral administration of human rotavirus to volunteers: Induction of illness and correlates of resistance

A. Z. Kapikian, R. G. Wyatt, M. M. Levine, D. H. Vankirk, H. B. Greenberg, R. M. Chanock, R. H. Yolken, R. Dolin

Research output: Contribution to journalArticle

Abstract

Four of 18 volunteers challenged orally with human rotavirus strain D (subgroup 2, serotype Wa) developed a diarrheal illness two to four days after inoculation. Viral shedding was detected in five of the 18 volunteers, whereas 12 (67%) developed serologic evidence of infection. Two volunteers who developed diarrheal illness after the initial inoculation were given the same inoculum 19 months later; neither developed diarrhea, although one developed constitutional and gastrointestinal symptoms. The presence of preinoculation serum immunofluorescent antibody to rotavirus strain D or high levels of neutralizing antibody to Wa or reassortant DS-l human rotavirus correlated with resistance to diarrheal illness. Although prechallenge serum antibody correlated with resistance to diarrhea and/or shedding of rotavirus, the relationship of preexisting local neutralizing activity in intestinal fluid was less clear-cut.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalJournal of Infectious Diseases
Volume147
Issue number1
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Kapikian, A. Z., Wyatt, R. G., Levine, M. M., Vankirk, D. H., Greenberg, H. B., Chanock, R. M., Yolken, R. H., & Dolin, R. (1983). Oral administration of human rotavirus to volunteers: Induction of illness and correlates of resistance. Journal of Infectious Diseases, 147(1), 95-106. https://doi.org/10.1093/infdis/147.1.95