Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain

Stephan Lammel, Gül Dölen, Robert C. Malenka

Research output: ResearchChapter

Abstract

Unraveling the structural and genetic complexity of the mammalian brain remains one of the greatest challenges for modern biomedical research. The advent of technologies that enable the molecular targeting of neurons in a cell type-specific manner holds great promise for circuit-level dissection of this complexity. Here we focus on a number of strategies to harness optogenetic advances for functional circuit analysis at the level of the delineation of necessary and sufficient circuits for behavioral analysis and the dissection of synaptic input specificity. These insights will be critical for understanding the pathophysiology of complex human neuropsychiatric disorders such as depression, anxiety disorders, drug addiction, and Parkinson disease.

LanguageEnglish (US)
Title of host publicationGenomics, Circuits, and Pathways in Clinical Neuropsychiatry
PublisherElsevier Inc.
Pages221-231
Number of pages11
ISBN (Print)9780128001059
DOIs
StatePublished - Jun 21 2016

Fingerprint

Optogenetics
Dissection
Brain
Anxiety Disorders
Substance-Related Disorders
Parkinson Disease
Biomedical Research
Depression
Technology
Neurons

Keywords

  • Channelrhodopsin
  • Halorhodopsin
  • Neuropsychiatric disorders
  • Opsins
  • Optogenetics
  • Rabies virus
  • Transgenic animals

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lammel, S., Dölen, G., & Malenka, R. C. (2016). Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain. In Genomics, Circuits, and Pathways in Clinical Neuropsychiatry (pp. 221-231). Elsevier Inc.. DOI: 10.1016/B978-0-12-800105-9.00014-7

Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain. / Lammel, Stephan; Dölen, Gül; Malenka, Robert C.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Elsevier Inc., 2016. p. 221-231.

Research output: ResearchChapter

Lammel, S, Dölen, G & Malenka, RC 2016, Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain. in Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Elsevier Inc., pp. 221-231. DOI: 10.1016/B978-0-12-800105-9.00014-7
Lammel S, Dölen G, Malenka RC. Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain. In Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Elsevier Inc.2016. p. 221-231. Available from, DOI: 10.1016/B978-0-12-800105-9.00014-7
Lammel, Stephan ; Dölen, Gül ; Malenka, Robert C./ Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Elsevier Inc., 2016. pp. 221-231
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