Opto-acoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma

Alexander A. Oraevsky, Alexander A. Karabutov, Elena B. Savateeva, Brent Bell, Massoud Motamedi, Sharon L. Thomsen, Pankaj Jay Pasricha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An otoacoustic transducer capable of detecting wide-band ultrasonic profiles at the site of pulsed laser irradiation was developed and applied in imaging various stages of squamous cell carcinoma produced in a hamster cheek pouch model. Imaging was performed using 12-nanosecond Nd:YAG laser pulses (FWHM) at the wavelength of 532 nm, which provided sufficient depth of monitoring (2 mm), significant tissue contrast and 15-μm in depth resolution. The opto-acoustic images depict distinct tissue layers in control (normal) animals and heterogeneous structureless tissue in pre-cancer and cancer stages. Pronounced changes in subsurface tissue structures that occur in the course of cancer development were not detected upon gross examination. Optoacoustic images of later stages in cancer development presented exophytic or irregular profiles on the surfaces, possibly associated with enhanced microvascularization. The changes associated with benign inflammation yielded optoacoustic images different from those depicting cancer progression. The experimental results suggest that the optoacoustic images displaying layered tissue structure on the basis of variations in optical absorption and scattering may be utilized for early detection and staging of superficial mucosa cancer.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages385-396
Number of pages12
Volume3597
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III - San Jose, CA, USA
Duration: Jan 24 1999Jan 28 1999

Other

OtherProceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III
CitySan Jose, CA, USA
Period1/24/991/28/99

Fingerprint

Acoustic imaging
acoustic imaging
hamsters
cancer
Photoacoustic effect
Tissue
Imaging techniques
Laser beam effects
Full width at half maximum
Pulsed lasers
Light absorption
Transducers
Laser pulses
Animals
Ultrasonics
Acoustics
profiles
Epithelial Cells
Scattering
progressions

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Oraevsky, A. A., Karabutov, A. A., Savateeva, E. B., Bell, B., Motamedi, M., Thomsen, S. L., & Pasricha, P. J. (1999). Opto-acoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 385-396). Society of Photo-Optical Instrumentation Engineers.

Opto-acoustic imaging of oral cancer : feasibility studies in hamster model of squamous cell carcinoma. / Oraevsky, Alexander A.; Karabutov, Alexander A.; Savateeva, Elena B.; Bell, Brent; Motamedi, Massoud; Thomsen, Sharon L.; Pasricha, Pankaj Jay.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3597 Society of Photo-Optical Instrumentation Engineers, 1999. p. 385-396.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oraevsky, AA, Karabutov, AA, Savateeva, EB, Bell, B, Motamedi, M, Thomsen, SL & Pasricha, PJ 1999, Opto-acoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3597, Society of Photo-Optical Instrumentation Engineers, pp. 385-396, Proceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III, San Jose, CA, USA, 1/24/99.
Oraevsky AA, Karabutov AA, Savateeva EB, Bell B, Motamedi M, Thomsen SL et al. Opto-acoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3597. Society of Photo-Optical Instrumentation Engineers. 1999. p. 385-396
Oraevsky, Alexander A. ; Karabutov, Alexander A. ; Savateeva, Elena B. ; Bell, Brent ; Motamedi, Massoud ; Thomsen, Sharon L. ; Pasricha, Pankaj Jay. / Opto-acoustic imaging of oral cancer : feasibility studies in hamster model of squamous cell carcinoma. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3597 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 385-396
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