Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists

Alice Y. Ho, Jean L. Wright, Rachel C. Blitzblau, Robert W. Mutter, Dan G. Duda, Larry Norton, Aditya Bardia, Laura Spring, Steven J. Isakoff, Jonathan H. Chen, Clemens Grassberger, Jennifer R. Bellon, Sushil Beriwal, Atif J. Khan, Corey Speers, Samantha A. Dunn, Alastair Thompson, Cesar A. Santa-Maria, Ian E. Krop, Elizabeth MittendorfTari A. King, Gaorav P. Gupta

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunotherapy using immune checkpoint blockade has revolutionized the treatment of many types of cancer. Radiation therapy (RT)—particularly when delivered at high doses using newer techniques—may be capable of generating systemic antitumor effects when combined with immunotherapy in breast cancer. These systemic effects might be due to the local immune-priming effects of RT resulting in the expansion and circulation of effector immune cells to distant sites. Although this concept merits further exploration, several challenges need to be overcome. One is an understanding of how the heterogeneity of breast cancers may relate to tumor immunogenicity. Another concerns the need to develop knowledge and expertise in delivery, sequencing, and timing of RT with immunotherapy. Clinical trials addressing these issues are under way. We here review and discuss the particular opportunities and issues regarding this topic, including the design of informative clinical and translational studies.

Original languageEnglish (US)
Pages (from-to)227-241
Number of pages15
JournalInternational Journal of Radiation Oncology Biology Physics
Volume108
Issue number1
DOIs
StatePublished - Sep 1 2020

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists'. Together they form a unique fingerprint.

Cite this