Optimized radiographic spectra for digital subtraction angiography in the mouse

Ming De Lin, Cristian T. Badea, G. Allan Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The availability of genetically altered mouse models of human disease and the increasing use of small animals in basic research have spurred extraordinary interest in new imaging methodologies - particularly magnetic resonance microscopy, microCT, and microPET. To date, very little attention has been given to planar radiographic imaging. Yet there exists enormous potential for this modality given the ease of use and its potential speed. Functional imaging in mouse models can be addressed particularly well through the use of digital subtraction angiography. We describe here a system designed explicitly for digital subtraction angiography in the mouse and the optimization of acquisition parameters required to perform the highest quality functional subtraction angiograms. We focus on optimization of contrast using selective K-edge filters and the optimization of contrast agent though a carefully controlled biological pulse sequence.

Original languageEnglish (US)
Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationMacro to Nano
Pages1412-1415
Number of pages4
StatePublished - Dec 1 2004
Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
Duration: Apr 15 2004Apr 18 2004

Publication series

Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume2

Other

Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
CountryUnited States
CityArlington, VA
Period4/15/044/18/04

ASJC Scopus subject areas

  • Engineering(all)

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