Optimized modification of the eighth edition of AJCC TNM staging system for resected pancreatic ductal adenocarcinoma

Ning Pu, Lingdi Yin, Joseph R. Habib, Shanshan Gao, Haijie Hu, Yayun Zhu, Yong Wu, Jun Yu, Wenhui Lou

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To reassess the prognostic performance of the American Joint Committee on Cancer (AJCC) 8th edition for pancreatic ductal adenocarcinoma (PDAC) and optimize the categorization of PDAC staging. Patients & methods: A total of 11,858 patients with resected PDAC from the Surveillance, Epidemiology and End Results database were retrospectively enrolled by sequential analyses. Results: There was no statistical significance between stage IIA and IIB tumors with hazard ratios of 2.065 and 2.184 (p = 0.620) for stages IIA and IIB, respectively. With the proposed modification, there was a significant difference between the hazard ratios of stages IIIA and IIIB which were 2.481 and 2.715, respectively (p = 0.009). The C-index of modified system was 0.609, slightly higher than AJCC 8th staging system 0.604. Conclusion: We proposed a modified eighth edition of the AJCC staging system by combining stage IIA with IIB and further subclassifying stage III patients in order to lead to better discriminative power.

Original languageEnglish (US)
Pages (from-to)3457-3465
Number of pages9
JournalFuture Oncology
Volume15
Issue number30
DOIs
StatePublished - 2019

Keywords

  • AJCC
  • pancreatic ductal adenocarcinoma
  • prognosis
  • risk
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Optimized modification of the eighth edition of AJCC TNM staging system for resected pancreatic ductal adenocarcinoma'. Together they form a unique fingerprint.

Cite this