Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid

Haifeng Zeng, Jiadi Xu, Joseph Gillen, Michael T. McMahon, Dmitri Artemov, Jean Max Tyburn, Joost A.B. Lohman, Ryan E. Mewis, Kevin D. Atkinson, Gary G.R. Green, Simon B. Duckett, Peter C.M. Van Zijl

Research output: Contribution to journalArticle

Abstract

Hyperpolarization produces nuclear spin polarization that is several orders of magnitude larger than that achieved at thermal equilibrium thus providing extraordinary contrast and sensitivity. As a parahydrogen induced polarization (PHIP) technique that does not require chemical modification of the substrate to polarize, Signal Amplification by Reversible Exchange (SABRE) has attracted a lot of attention. Using a prototype parahydrogen polarizer, we polarize two drugs used in the treatment of tuberculosis, namely pyrazinamide and isoniazid. We examine this approach in four solvents, methanol-d4, methanol, ethanol and DMSO and optimize the polarization transfer magnetic field strength, the temperature as well as intensity and duration of hydrogen bubbling to achieve the best overall signal enhancement and hence hyperpolarization level.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalJournal of Magnetic Resonance
Volume237
DOIs
StatePublished - Oct 22 2013

Keywords

  • Hyperpolarization
  • Isoniazid
  • Mycobacterium Tuberculosis
  • Parahydrogen
  • Pyrazinamide
  • SABRE

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid'. Together they form a unique fingerprint.

  • Cite this