Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection

Tang Ling, Arman Rahmim, Riikka Lautämaki, Martin Lodge, Frank M. Bengel, Benjamin Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study is to optimize the dynamicRb-82 myocardial perfusion (MP) PET acquisition/reconstruction protocols for maximum perfusion defect detection using realistic simulation data and task-based evaluation. Time activity curves (TACs) of different organs at both rest and stress conditions were extracted from dynamic Rb-82 PET images of 5 normal patients. Combined SimSET-GATE Monte Carlo simulation was used to generate nearly noise-free (NNF) MP PET data from a time series of 3D NCAT phantoms with organ activities modeling difTerent pre-scan delay times (PDTs) and total acquisition times (TATs). Poisson noise was added to the NNF projections and the OS-EM algorithm was applied to generate noisy reconstructed images. The channelized Hotelling observer (CHO) with 32x32 spatial templates corresponding to 4 octave-wide frequency channels was used to evaluate the images. The area under the ROC curve (AVC) was calculated from the CHO rating data as an index for image quality in terms of MP defec detection. The 0.5 cycle/cm Butterworth post-filtering on OS-EM (with 21 subsets) reconstructed images generates the highest AVC values while those from iteration number 1 to 4 do not show different AVC values. The optimized PDTs for both rest and stress conditions are found to be close to the cross points of the left ventricular chamber and myocardium TACs, which may promote individualized PDT for patient data processing and image reconstruction. Shortening the TATs for

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages4629-4635
Number of pages7
DOIs
StatePublished - 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

Fingerprint

Perfusion
optimization
defects
acquisition
time lag
organs
Noise
curves
GARP Atlantic Tropical Experiment
myocardium
octaves
ratings
data simulation
image reconstruction
set theory
iteration
templates
chambers
projection
Computer-Assisted Image Processing

Keywords

  • Acquisition/ Reconstruction protocol optimization
  • Rb-82 myocardial perfusion PET

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Ling, T., Rahmim, A., Lautämaki, R., Lodge, M., Bengel, F. M., & Tsui, B. (2008). Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection. In IEEE Nuclear Science Symposium Conference Record (pp. 4629-4635). [4774430] https://doi.org/10.1109/NSSMIC.2008.4774430

Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection. / Ling, Tang; Rahmim, Arman; Lautämaki, Riikka; Lodge, Martin; Bengel, Frank M.; Tsui, Benjamin.

IEEE Nuclear Science Symposium Conference Record. 2008. p. 4629-4635 4774430.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ling, T, Rahmim, A, Lautämaki, R, Lodge, M, Bengel, FM & Tsui, B 2008, Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection. in IEEE Nuclear Science Symposium Conference Record., 4774430, pp. 4629-4635, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774430
Ling T, Rahmim A, Lautämaki R, Lodge M, Bengel FM, Tsui B. Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection. In IEEE Nuclear Science Symposium Conference Record. 2008. p. 4629-4635. 4774430 https://doi.org/10.1109/NSSMIC.2008.4774430
Ling, Tang ; Rahmim, Arman ; Lautämaki, Riikka ; Lodge, Martin ; Bengel, Frank M. ; Tsui, Benjamin. / Optimization of rb-82 PET aquisition and reconstruction protocols for myocardial perfusion defect detection. IEEE Nuclear Science Symposium Conference Record. 2008. pp. 4629-4635
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