Abstract
Background: At this time, several antibiotics have been investigated as possibilities for aerosol administration, but local therapy has been found to be more efficient in several diseases. Materials and methods: The drugs linezolid (Zyvox), vancomycin (Voncon), and daptomycin (Cubicin) were tested with three jet nebulizers with seven different residual cups and different loadings. Moreover, three ultrasound nebulizers were again tested with these drugs, with different loadings and mouthpiece attachments. Results: When drugs are combined with particular cup designs, they significantly lower the droplet size to 1.60 and 1.80 μm, which represents the best combination of Zyvox and cup G and Cubicin and cup D, respectively. Cup design D is suggested as the most effective cup for lowering the droplet size (2.30 μm) when considering a higher loading level (8 mL). Conclusion: Modification of current drugs from dry powder to solution is possible, and the residual cup design plays the most important role in droplet size production when the nebulization systems have the same properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1065-1072 |
| Number of pages | 8 |
| Journal | Drug Design, Development and Therapy |
| Volume | 8 |
| DOIs | |
| State | Published - Aug 12 2014 |
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Keywords
- Aerosol
- Daptomycin
- Jet nebulizers
- Linezolid
- Ultrasound nebulizers
- Vancomycin
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
- Medicine(all)
Cite this
Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol. / Zarogoulidis, Paul; Kioumis, Ioannis; Lampaki, Sofia; Organtzis, John; Porpodis, Konstantinos; Spyratos, Dionysios; Pitsiou, Georgia; Petridis, Dimitris; Pataka, Athanasia; Huang, Haidong; Li, Qiang; Yarmus, Lonny; Hohenforst-Schmidt, Wolfgang; Pezirkianidis, Nikolaos; Zarogoulidis, Konstantinos.
In: Drug Design, Development and Therapy, Vol. 8, 12.08.2014, p. 1065-1072.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol
AU - Zarogoulidis, Paul
AU - Kioumis, Ioannis
AU - Lampaki, Sofia
AU - Organtzis, John
AU - Porpodis, Konstantinos
AU - Spyratos, Dionysios
AU - Pitsiou, Georgia
AU - Petridis, Dimitris
AU - Pataka, Athanasia
AU - Huang, Haidong
AU - Li, Qiang
AU - Yarmus, Lonny
AU - Hohenforst-Schmidt, Wolfgang
AU - Pezirkianidis, Nikolaos
AU - Zarogoulidis, Konstantinos
PY - 2014/8/12
Y1 - 2014/8/12
N2 - Background: At this time, several antibiotics have been investigated as possibilities for aerosol administration, but local therapy has been found to be more efficient in several diseases. Materials and methods: The drugs linezolid (Zyvox), vancomycin (Voncon), and daptomycin (Cubicin) were tested with three jet nebulizers with seven different residual cups and different loadings. Moreover, three ultrasound nebulizers were again tested with these drugs, with different loadings and mouthpiece attachments. Results: When drugs are combined with particular cup designs, they significantly lower the droplet size to 1.60 and 1.80 μm, which represents the best combination of Zyvox and cup G and Cubicin and cup D, respectively. Cup design D is suggested as the most effective cup for lowering the droplet size (2.30 μm) when considering a higher loading level (8 mL). Conclusion: Modification of current drugs from dry powder to solution is possible, and the residual cup design plays the most important role in droplet size production when the nebulization systems have the same properties.
AB - Background: At this time, several antibiotics have been investigated as possibilities for aerosol administration, but local therapy has been found to be more efficient in several diseases. Materials and methods: The drugs linezolid (Zyvox), vancomycin (Voncon), and daptomycin (Cubicin) were tested with three jet nebulizers with seven different residual cups and different loadings. Moreover, three ultrasound nebulizers were again tested with these drugs, with different loadings and mouthpiece attachments. Results: When drugs are combined with particular cup designs, they significantly lower the droplet size to 1.60 and 1.80 μm, which represents the best combination of Zyvox and cup G and Cubicin and cup D, respectively. Cup design D is suggested as the most effective cup for lowering the droplet size (2.30 μm) when considering a higher loading level (8 mL). Conclusion: Modification of current drugs from dry powder to solution is possible, and the residual cup design plays the most important role in droplet size production when the nebulization systems have the same properties.
KW - Aerosol
KW - Daptomycin
KW - Jet nebulizers
KW - Linezolid
KW - Ultrasound nebulizers
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=84906223626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906223626&partnerID=8YFLogxK
U2 - 10.2147/DDDT.S66576
DO - 10.2147/DDDT.S66576
M3 - Article
C2 - 25143711
AN - SCOPUS:84906223626
VL - 8
SP - 1065
EP - 1072
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
SN - 1177-8881
ER -