Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions

W. E. Braun; A. C. Novick; D. R. Steinmuller; S. Jayavant; J. Mogor; T. Williams; C. Dejelo; N. Murphy; A. Zachary; D. Protiva; C. Buszta

doi:10.3949/ccjm.49.2.79

Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions

W. E. Braun, A. C. Novick, D. R. Steinmuller, S. Jayavant, J. Mogor, T. Williams, C. Dejelo, N. Murphy, A. Zachary, D. Protiva, C. Buszta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The approach outlined here has provided an effective means of improving allograft survival, with 6-month survivals of 90% or better for every type of living-related transplant, i.e., HLA-identical siblings, nonidentical recipients with low MLCs, and nonidentical recipients with high MLCs given DSTs. Our center has confirmed the basic findings originally presented by the San Fransisco transplantation team. To those findings can now be added data to suggest that certain pairs of mismatched DR antigens are associated with either high or low MLC activity, specifically, DR3-DR6, DR4-DR Blank, and DR6-DR7 in the former group, and DR4-DR7 and DR6-DR Blank in the latter.

Original language	English (US)
Pages (from-to)	79-85
Number of pages	7
Journal	Unknown Journal
Volume	49
Issue number	2
DOIs	https://doi.org/10.3949/ccjm.49.2.79
State	Published - 1982

ASJC Scopus subject areas

Medicine(all)

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Braun, W. E., Novick, A. C., Steinmuller, D. R., Jayavant, S., Mogor, J., Williams, T., Dejelo, C., Murphy, N., Zachary, A., Protiva, D., & Buszta, C. (1982). Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions. Unknown Journal, 49(2), 79-85. https://doi.org/10.3949/ccjm.49.2.79

Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions. / Braun, W. E.; Novick, A. C.; Steinmuller, D. R.; Jayavant, S.; Mogor, J.; Williams, T.; Dejelo, C.; Murphy, N.; Zachary, A.; Protiva, D.; Buszta, C.

In: Unknown Journal, Vol. 49, No. 2, 1982, p. 79-85.

Research output: Contribution to journal › Article › peer-review

Braun, WE, Novick, AC, Steinmuller, DR, Jayavant, S, Mogor, J, Williams, T, Dejelo, C, Murphy, N, Zachary, A, Protiva, D & Buszta, C 1982, 'Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions', Unknown Journal, vol. 49, no. 2, pp. 79-85. https://doi.org/10.3949/ccjm.49.2.79

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abstract = "The approach outlined here has provided an effective means of improving allograft survival, with 6-month survivals of 90% or better for every type of living-related transplant, i.e., HLA-identical siblings, nonidentical recipients with low MLCs, and nonidentical recipients with high MLCs given DSTs. Our center has confirmed the basic findings originally presented by the San Fransisco transplantation team. To those findings can now be added data to suggest that certain pairs of mismatched DR antigens are associated with either high or low MLC activity, specifically, DR3-DR6, DR4-DR Blank, and DR6-DR7 in the former group, and DR4-DR7 and DR6-DR Blank in the latter.",

author = "Braun, {W. E.} and Novick, {A. C.} and Steinmuller, {D. R.} and S. Jayavant and J. Mogor and T. Williams and C. Dejelo and N. Murphy and A. Zachary and D. Protiva and C. Buszta",

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AU - Braun, W. E.

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AU - Steinmuller, D. R.

AU - Jayavant, S.

AU - Mogor, J.

AU - Williams, T.

AU - Dejelo, C.

AU - Murphy, N.

AU - Zachary, A.

AU - Protiva, D.

AU - Buszta, C.

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AB - The approach outlined here has provided an effective means of improving allograft survival, with 6-month survivals of 90% or better for every type of living-related transplant, i.e., HLA-identical siblings, nonidentical recipients with low MLCs, and nonidentical recipients with high MLCs given DSTs. Our center has confirmed the basic findings originally presented by the San Fransisco transplantation team. To those findings can now be added data to suggest that certain pairs of mismatched DR antigens are associated with either high or low MLC activity, specifically, DR3-DR6, DR4-DR Blank, and DR6-DR7 in the former group, and DR4-DR7 and DR6-DR Blank in the latter.

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Optimization of living-related renal transplantation success through HLA genotyping, MLC stimulation cutoffs, and donor-specific blood transfusions

Abstract

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