Optimization of fast acquisition methods for whole-brain relative cerebral blood volume (rCBV) mapping with susceptibility contrast agents

L. Hou, Y. Yang, V. S. Mattay, J. A. Frank, J. H. Duyn

Research output: Contribution to journalArticle


Fast gradient-echo magnetic resonance scan techniques with spiral and rectilinear (echoplanar) k-space trajectories were optimized to perform bolus-tracking studies of human brain. Cerebral hemodynamics were studied with full brain coverage, a spatial resolution of 4 mm, and a temporal resolution of 2 seconds. The sensitivity of the techniques to detect image signal-intensity changes during the first pass of the contrast agent was studied at a range of TEs using dedicated experiments. For single-shot versions of spiral scanning and echoplanar imaging techniques with a 0.1- mmol/kg injection of gadolinium diethylenetriamine pentaacetic acid using a mechanical injector at 10 mL/sec under 1.5 T, the maximum sensitivity was obtained at TEs between 35 and 45 msec. At TEs less than 35 msec, signal- intensity artifacts were observed in the images. Analysis of the point- spread function revealed that susceptibility changes induced by the contrast agent can result in signal shifts to neighboring voxels. These artifacts are attributed to susceptibility-related signal changes during the acquisition window.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Mar 16 1999
Externally publishedYes



  • Bolus tracking (BT)
  • CBV
  • EPI
  • Perfusion
  • Spiral imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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