Optimal timing of retinal scanning during dark adaptation, in the presence of fixation on a target: The role of pupil size dynamics

Research output: Contribution to journalArticle

Abstract

While validating our newly developed vision screener based on a double-pass retinal scanning system, we noticed that in all patients the signals from the retina were significantly higher when measurements were performed within a certain time interval referenced to the initial moment when the lights were dimmed and the test subject was asked to fixate on a target. This appeared to be most likely attributable to pupil size dynamics and triggered the present study, whose aim was to assess the pupillary "lights-off" response while fixating on a target in the presence of an accommodative effort. We found that pupil size increases in the first 60 to 70 s after turning off the room lights, and then it decreases toward the baseline in an exponential decay. Our results suggest that there is an optimal time window during which pupil size is expected to be maximal, that is during the second minute after dimming the room lights. During this time, window retinal diagnostic instruments based on doublepass measurement technology should deliver an optimal signal-to-noise ratio. We also propose a mathematical model that can be used to approximate the behavior of the normalized pupil size.

Original languageEnglish (US)
Article number106014
JournalJournal of Biomedical Optics
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2014

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dark adaptation
pupil size
Dark Adaptation
Pupil
luminaires
time measurement
Scanning
Light
scanning
rooms
Dimming (lamps)
dimming
retina
Signal-To-Noise Ratio
Retina
mathematical models
Signal to noise ratio
signal to noise ratios
Theoretical Models
Mathematical models

Keywords

  • Accommodation
  • Dark adaptation
  • Fixation
  • Pupil dynamics
  • Retinal scanning

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

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abstract = "While validating our newly developed vision screener based on a double-pass retinal scanning system, we noticed that in all patients the signals from the retina were significantly higher when measurements were performed within a certain time interval referenced to the initial moment when the lights were dimmed and the test subject was asked to fixate on a target. This appeared to be most likely attributable to pupil size dynamics and triggered the present study, whose aim was to assess the pupillary {"}lights-off{"} response while fixating on a target in the presence of an accommodative effort. We found that pupil size increases in the first 60 to 70 s after turning off the room lights, and then it decreases toward the baseline in an exponential decay. Our results suggest that there is an optimal time window during which pupil size is expected to be maximal, that is during the second minute after dimming the room lights. During this time, window retinal diagnostic instruments based on doublepass measurement technology should deliver an optimal signal-to-noise ratio. We also propose a mathematical model that can be used to approximate the behavior of the normalized pupil size.",
keywords = "Accommodation, Dark adaptation, Fixation, Pupil dynamics, Retinal scanning",
author = "Boris Gramatikov and Kristina Irsch and Guyton, {David Lee}",
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AU - Guyton, David Lee

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