Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data

Gautam Kumar; Vikram Aggarwal; Nitish V. Thakor; Marc H. Schieber; Mayuresh V. Kothare

doi:10.1109/acc.2010.5530803

Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data

Gautam Kumar, Vikram Aggarwal, Nitish V. Thakor, Marc H. Schieber, Mayuresh V. Kothare

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

We propose to use the Izhikevich single neuron model to represent a motor cortex neuron for studying a control-theoretic perspective of a neuroprosthetic system. The problem of estimating model parameters is addressed when the only available data from intracortical recordings of a neuron are the Inter-Spike Intervals (ISIs). Non-linear constrained and unconstrained optimization problems are formulated to estimate model parameters as well as synaptic inputs using ISIs data. The primal-dual interior-point method is implemented to solve the constrained optimization problem. Reasonable model parameters are estimated by solving these optimization problems which may serve as a template for studying and developing a model of ensemble cortical neurons for neuroprosthesis applications.

Original language	English (US)
Title of host publication	Proceedings of the 2010 American Control Conference, ACC 2010
Publisher	IEEE Computer Society
Pages	3586-3591
Number of pages	6
ISBN (Print)	9781424474264
DOIs	https://doi.org/10.1109/acc.2010.5530803
State	Published - 2010

Publication series

Name	Proceedings of the 2010 American Control Conference, ACC 2010

ASJC Scopus subject areas

Control and Systems Engineering

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10.1109/acc.2010.5530803

Cite this

Kumar, G., Aggarwal, V., Thakor, N. V., Schieber, M. H., & Kothare, M. V. (2010). Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data. In Proceedings of the 2010 American Control Conference, ACC 2010 (pp. 3586-3591). Article 5530803 (Proceedings of the 2010 American Control Conference, ACC 2010). IEEE Computer Society. https://doi.org/10.1109/acc.2010.5530803

Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data. / Kumar, Gautam; Aggarwal, Vikram; Thakor, Nitish V. et al.
Proceedings of the 2010 American Control Conference, ACC 2010. IEEE Computer Society, 2010. p. 3586-3591 5530803 (Proceedings of the 2010 American Control Conference, ACC 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kumar, G, Aggarwal, V, Thakor, NV, Schieber, MH & Kothare, MV 2010, Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data. in Proceedings of the 2010 American Control Conference, ACC 2010., 5530803, Proceedings of the 2010 American Control Conference, ACC 2010, IEEE Computer Society, pp. 3586-3591. https://doi.org/10.1109/acc.2010.5530803

Kumar G, Aggarwal V, Thakor NV, Schieber MH, Kothare MV. Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data. In Proceedings of the 2010 American Control Conference, ACC 2010. IEEE Computer Society. 2010. p. 3586-3591. 5530803. (Proceedings of the 2010 American Control Conference, ACC 2010). doi: 10.1109/acc.2010.5530803

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Optimal parameter estimation of the Izhikevich single neuron model using experimental Inter-Spike Interval (ISI) data

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