Optimal Human Passive Vestibulo-Ocular Reflex Adaptation Does Not Rely on Passive Training

M. Muntaseer Mahfuz, Michael C Schubert, William V.C. Figtree, Christopher J. Todd, Serajul I. Khan, Americo A. Migliaccio

Research output: Contribution to journalArticle

Abstract

The vestibulo-ocular reflex (VOR) is the main vision-stabilising system during rapid head movements in humans. A visual-vestibular mismatch stimulus can be used to train or adapt the VOR response because it induces a retinal image slip error signal that drives VOR motor learning. The training context has been shown to affect VOR adaptation. We sought to determine whether active (self-generated) versus passive (externally imposed) head rotation vestibular training would differentially affect adaptation and short-term retention of the active and passive VOR responses. Ten subjects were tested, each over six separate 1.5-h sessions. We compared active versus passive head impulse (transient, rapid head rotations with peak velocity ~ 150 °/s) VOR adaptation training lasting 15 min with the VOR gain challenged to increment, starting at unity, by 0.1 every 90 s towards one side only (this adapting side was randomised to be either left or right). The VOR response was tested/measured in darkness at 10-min intervals, 20-min intervals, and two single 60-min interval sessions for 1 h post-training. The training was active or passive for the 10- and 20-min interval sessions, but only active for the two single 60-min interval sessions. The mean VOR response increase due to training was ~ 10 % towards the adapting side versus ~2 % towards the non-adapting side. There was no difference in VOR adaptation and retention between active and passive VOR training. The only factor to affect retention was exposure to a de-adaptation stimulus. These data suggest that active VOR adaptation training can be used to optimally adapt the passive VOR and that adaptation is completely retained over 1 h as long as there is no visual feedback signal driving de-adaptation.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJARO - Journal of the Association for Research in Otolaryngology
DOIs
StateAccepted/In press - Feb 20 2018

Fingerprint

Ocular Adaptation
Vestibulo-Ocular Reflex
Head
Head Movements
Sensory Feedback
Darkness

Keywords

  • active and passive VOR
  • retention of VOR adaptation
  • vestibulo-ocular reflex (VOR)
  • VOR adaptation
  • VOR training

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems

Cite this

Optimal Human Passive Vestibulo-Ocular Reflex Adaptation Does Not Rely on Passive Training. / Mahfuz, M. Muntaseer; Schubert, Michael C; Figtree, William V.C.; Todd, Christopher J.; Khan, Serajul I.; Migliaccio, Americo A.

In: JARO - Journal of the Association for Research in Otolaryngology, 20.02.2018, p. 1-11.

Research output: Contribution to journalArticle

Mahfuz, M. Muntaseer ; Schubert, Michael C ; Figtree, William V.C. ; Todd, Christopher J. ; Khan, Serajul I. ; Migliaccio, Americo A. / Optimal Human Passive Vestibulo-Ocular Reflex Adaptation Does Not Rely on Passive Training. In: JARO - Journal of the Association for Research in Otolaryngology. 2018 ; pp. 1-11.
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abstract = "The vestibulo-ocular reflex (VOR) is the main vision-stabilising system during rapid head movements in humans. A visual-vestibular mismatch stimulus can be used to train or adapt the VOR response because it induces a retinal image slip error signal that drives VOR motor learning. The training context has been shown to affect VOR adaptation. We sought to determine whether active (self-generated) versus passive (externally imposed) head rotation vestibular training would differentially affect adaptation and short-term retention of the active and passive VOR responses. Ten subjects were tested, each over six separate 1.5-h sessions. We compared active versus passive head impulse (transient, rapid head rotations with peak velocity ~ 150 °/s) VOR adaptation training lasting 15 min with the VOR gain challenged to increment, starting at unity, by 0.1 every 90 s towards one side only (this adapting side was randomised to be either left or right). The VOR response was tested/measured in darkness at 10-min intervals, 20-min intervals, and two single 60-min interval sessions for 1 h post-training. The training was active or passive for the 10- and 20-min interval sessions, but only active for the two single 60-min interval sessions. The mean VOR response increase due to training was ~ 10 {\%} towards the adapting side versus ~2 {\%} towards the non-adapting side. There was no difference in VOR adaptation and retention between active and passive VOR training. The only factor to affect retention was exposure to a de-adaptation stimulus. These data suggest that active VOR adaptation training can be used to optimally adapt the passive VOR and that adaptation is completely retained over 1 h as long as there is no visual feedback signal driving de-adaptation.",
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