Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona

Translated title of the contribution: Optimal cut-point of salivary cotinine concentration to discriminate smoking status in the adult population in Barcelona

Jose M. Martínez-Sánchez, Marcela Fu, Carles Ariza, María J. López, Esteve Saltó, José A. Pascual, Anna Schiaffino, Josep M. Borràs, Mercè Peris, Antonio Agudo, Manel Nebot, Esteve Fernández

Research output: Contribution to journalArticle

Abstract

Objective: To assess the optimal cut-point for salivary cotinine concentration to identify smoking status in the adult population of Barcelona. Methods: We performed a cross-sectional study of a representative sample (n=1,117) of the adult population (>16 years) in Barcelona (2004-2005). This study gathered information on active and passive smoking by means of a questionnaire and a saliva sample for cotinine determination. We analyzed sensitivity and specificity according to sex, age, smoking status (daily and occasional), and exposure to second-hand smoke at home. ROC curves and the area under the curve were calculated. Results: The prevalence of smokers (daily and occasional) was 27.8% (95% CI: 25.2-30.4%). The optimal cut-point to discriminate smoking status was 9.2 ng/ml (sensitivity=88.7% and specificity=89.0%). The area under the ROC curve was 0.952. The optimal cut-point was 12.2 ng/ml in men and 7.6 ng/ml in women. The optimal cut-point was higher at ages with a greater prevalence of smoking. Daily smokers had a higher cut-point than occasional smokers. Conclusions: The optimal cut-point to discriminate smoking status in the adult population is 9.2 ng/ml, with sensitivities and specificities around 90%. The cut-point was higher in men and in younger people. The cut-point increases with higher prevalence of daily smokers.

Original languageSpanish
Pages (from-to)501-505
Number of pages5
JournalGaceta sanitaria / S.E.S.P.A.S
Volume23
Issue number6
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Cotinine
Smoking
Tobacco Smoke Pollution
Population
Sensitivity and Specificity
ROC Curve
Area Under Curve
Saliva
Cross-Sectional Studies

Keywords

  • Cotinine
  • Cut-off point
  • ROC curve
  • Sensitivity
  • Smoking
  • Specificity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona. / Martínez-Sánchez, Jose M.; Fu, Marcela; Ariza, Carles; López, María J.; Saltó, Esteve; Pascual, José A.; Schiaffino, Anna; Borràs, Josep M.; Peris, Mercè; Agudo, Antonio; Nebot, Manel; Fernández, Esteve.

In: Gaceta sanitaria / S.E.S.P.A.S, Vol. 23, No. 6, 11.2009, p. 501-505.

Research output: Contribution to journalArticle

Martínez-Sánchez, JM, Fu, M, Ariza, C, López, MJ, Saltó, E, Pascual, JA, Schiaffino, A, Borràs, JM, Peris, M, Agudo, A, Nebot, M & Fernández, E 2009, 'Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona', Gaceta sanitaria / S.E.S.P.A.S, vol. 23, no. 6, pp. 501-505. https://doi.org/10.1016/j.gaceta.2009.03.003
Martínez-Sánchez, Jose M. ; Fu, Marcela ; Ariza, Carles ; López, María J. ; Saltó, Esteve ; Pascual, José A. ; Schiaffino, Anna ; Borràs, Josep M. ; Peris, Mercè ; Agudo, Antonio ; Nebot, Manel ; Fernández, Esteve. / Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona. In: Gaceta sanitaria / S.E.S.P.A.S. 2009 ; Vol. 23, No. 6. pp. 501-505.
@article{91a00785b1e74924b57bbb563c3651b0,
title = "Punto de corte {\'o}ptimo de la concentraci{\'o}n de cotinina en saliva para discriminar entre fumadores y no fumadores en la poblaci{\'o}n adulta de Barcelona",
abstract = "Objective: To assess the optimal cut-point for salivary cotinine concentration to identify smoking status in the adult population of Barcelona. Methods: We performed a cross-sectional study of a representative sample (n=1,117) of the adult population (>16 years) in Barcelona (2004-2005). This study gathered information on active and passive smoking by means of a questionnaire and a saliva sample for cotinine determination. We analyzed sensitivity and specificity according to sex, age, smoking status (daily and occasional), and exposure to second-hand smoke at home. ROC curves and the area under the curve were calculated. Results: The prevalence of smokers (daily and occasional) was 27.8{\%} (95{\%} CI: 25.2-30.4{\%}). The optimal cut-point to discriminate smoking status was 9.2 ng/ml (sensitivity=88.7{\%} and specificity=89.0{\%}). The area under the ROC curve was 0.952. The optimal cut-point was 12.2 ng/ml in men and 7.6 ng/ml in women. The optimal cut-point was higher at ages with a greater prevalence of smoking. Daily smokers had a higher cut-point than occasional smokers. Conclusions: The optimal cut-point to discriminate smoking status in the adult population is 9.2 ng/ml, with sensitivities and specificities around 90{\%}. The cut-point was higher in men and in younger people. The cut-point increases with higher prevalence of daily smokers.",
keywords = "Cotinine, Cut-off point, ROC curve, Sensitivity, Smoking, Specificity",
author = "Mart{\'i}nez-S{\'a}nchez, {Jose M.} and Marcela Fu and Carles Ariza and L{\'o}pez, {Mar{\'i}a J.} and Esteve Salt{\'o} and Pascual, {Jos{\'e} A.} and Anna Schiaffino and Borr{\`a}s, {Josep M.} and Merc{\`e} Peris and Antonio Agudo and Manel Nebot and Esteve Fern{\'a}ndez",
year = "2009",
month = "11",
doi = "10.1016/j.gaceta.2009.03.003",
language = "Spanish",
volume = "23",
pages = "501--505",
journal = "Gaceta Sanitaria",
issn = "0213-9111",
publisher = "Ediciones Doyma, S.L.",
number = "6",

}

TY - JOUR

T1 - Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona

AU - Martínez-Sánchez, Jose M.

AU - Fu, Marcela

AU - Ariza, Carles

AU - López, María J.

AU - Saltó, Esteve

AU - Pascual, José A.

AU - Schiaffino, Anna

AU - Borràs, Josep M.

AU - Peris, Mercè

AU - Agudo, Antonio

AU - Nebot, Manel

AU - Fernández, Esteve

PY - 2009/11

Y1 - 2009/11

N2 - Objective: To assess the optimal cut-point for salivary cotinine concentration to identify smoking status in the adult population of Barcelona. Methods: We performed a cross-sectional study of a representative sample (n=1,117) of the adult population (>16 years) in Barcelona (2004-2005). This study gathered information on active and passive smoking by means of a questionnaire and a saliva sample for cotinine determination. We analyzed sensitivity and specificity according to sex, age, smoking status (daily and occasional), and exposure to second-hand smoke at home. ROC curves and the area under the curve were calculated. Results: The prevalence of smokers (daily and occasional) was 27.8% (95% CI: 25.2-30.4%). The optimal cut-point to discriminate smoking status was 9.2 ng/ml (sensitivity=88.7% and specificity=89.0%). The area under the ROC curve was 0.952. The optimal cut-point was 12.2 ng/ml in men and 7.6 ng/ml in women. The optimal cut-point was higher at ages with a greater prevalence of smoking. Daily smokers had a higher cut-point than occasional smokers. Conclusions: The optimal cut-point to discriminate smoking status in the adult population is 9.2 ng/ml, with sensitivities and specificities around 90%. The cut-point was higher in men and in younger people. The cut-point increases with higher prevalence of daily smokers.

AB - Objective: To assess the optimal cut-point for salivary cotinine concentration to identify smoking status in the adult population of Barcelona. Methods: We performed a cross-sectional study of a representative sample (n=1,117) of the adult population (>16 years) in Barcelona (2004-2005). This study gathered information on active and passive smoking by means of a questionnaire and a saliva sample for cotinine determination. We analyzed sensitivity and specificity according to sex, age, smoking status (daily and occasional), and exposure to second-hand smoke at home. ROC curves and the area under the curve were calculated. Results: The prevalence of smokers (daily and occasional) was 27.8% (95% CI: 25.2-30.4%). The optimal cut-point to discriminate smoking status was 9.2 ng/ml (sensitivity=88.7% and specificity=89.0%). The area under the ROC curve was 0.952. The optimal cut-point was 12.2 ng/ml in men and 7.6 ng/ml in women. The optimal cut-point was higher at ages with a greater prevalence of smoking. Daily smokers had a higher cut-point than occasional smokers. Conclusions: The optimal cut-point to discriminate smoking status in the adult population is 9.2 ng/ml, with sensitivities and specificities around 90%. The cut-point was higher in men and in younger people. The cut-point increases with higher prevalence of daily smokers.

KW - Cotinine

KW - Cut-off point

KW - ROC curve

KW - Sensitivity

KW - Smoking

KW - Specificity

UR - http://www.scopus.com/inward/record.url?scp=70450224261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70450224261&partnerID=8YFLogxK

U2 - 10.1016/j.gaceta.2009.03.003

DO - 10.1016/j.gaceta.2009.03.003

M3 - Article

C2 - 19573954

AN - SCOPUS:70450224261

VL - 23

SP - 501

EP - 505

JO - Gaceta Sanitaria

JF - Gaceta Sanitaria

SN - 0213-9111

IS - 6

ER -