Punto de corte óptimo de la concentración de cotinina en saliva para discriminar entre fumadores y no fumadores en la población adulta de Barcelona

Translated title of the contribution: Optimal cut-point of salivary cotinine concentration to discriminate smoking status in the adult population in Barcelona

Jose M. Martínez-Sánchez, Marcela Fu, Carles Ariza, María J. López, Esteve Saltó, José A. Pascual, Anna Schiaffino, Josep M. Borràs, Mercè Peris, Antonio Agudo, Manel Nebot, Esteve Fernández

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the optimal cut-point for salivary cotinine concentration to identify smoking status in the adult population of Barcelona. Methods: We performed a cross-sectional study of a representative sample (n=1,117) of the adult population (>16 years) in Barcelona (2004-2005). This study gathered information on active and passive smoking by means of a questionnaire and a saliva sample for cotinine determination. We analyzed sensitivity and specificity according to sex, age, smoking status (daily and occasional), and exposure to second-hand smoke at home. ROC curves and the area under the curve were calculated. Results: The prevalence of smokers (daily and occasional) was 27.8% (95% CI: 25.2-30.4%). The optimal cut-point to discriminate smoking status was 9.2 ng/ml (sensitivity=88.7% and specificity=89.0%). The area under the ROC curve was 0.952. The optimal cut-point was 12.2 ng/ml in men and 7.6 ng/ml in women. The optimal cut-point was higher at ages with a greater prevalence of smoking. Daily smokers had a higher cut-point than occasional smokers. Conclusions: The optimal cut-point to discriminate smoking status in the adult population is 9.2 ng/ml, with sensitivities and specificities around 90%. The cut-point was higher in men and in younger people. The cut-point increases with higher prevalence of daily smokers.

Translated title of the contributionOptimal cut-point of salivary cotinine concentration to discriminate smoking status in the adult population in Barcelona
Original languageSpanish
Pages (from-to)501-505
Number of pages5
JournalGaceta Sanitaria
Volume23
Issue number6
DOIs
StatePublished - 2009

Keywords

  • Cotinine
  • Cut-off point
  • ROC curve
  • Sensitivity
  • Smoking
  • Specificity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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