Optimal clinical management of children receiving dietary therapies for epilepsy

Updated recommendations of the International Ketogenic Diet Study Group

The Charlie Foundation, Matthew's Friends, the Practice Committee of the Child Neurology Society

Research output: Contribution to journalArticle

Abstract

Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

Original languageEnglish (US)
Pages (from-to)175-192
Number of pages18
JournalEpilepsia Open
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2018

Fingerprint

Ketogenic Diet
Epilepsy
Therapeutics
Consensus
Guidelines
Patient Selection
Multicenter Studies
Uncertainty
Counseling
Clinical Trials
Diet

Keywords

  • Children
  • Diet
  • Epilepsy
  • Guideline
  • Ketogenic

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Optimal clinical management of children receiving dietary therapies for epilepsy : Updated recommendations of the International Ketogenic Diet Study Group. / The Charlie Foundation; Matthew's Friends; the Practice Committee of the Child Neurology Society.

In: Epilepsia Open, Vol. 3, No. 2, 01.01.2018, p. 175-192.

Research output: Contribution to journalArticle

The Charlie Foundation, Matthew's Friends & the Practice Committee of the Child Neurology Society 2018, 'Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group', Epilepsia Open, vol. 3, no. 2, pp. 175-192. https://doi.org/10.1002/epi4.12225
The Charlie Foundation ; Matthew's Friends ; the Practice Committee of the Child Neurology Society. / Optimal clinical management of children receiving dietary therapies for epilepsy : Updated recommendations of the International Ketogenic Diet Study Group. In: Epilepsia Open. 2018 ; Vol. 3, No. 2. pp. 175-192.
@article{1e9891ac02d04738b4dc698ba33b0906,
title = "Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group",
abstract = "Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.",
keywords = "Children, Diet, Epilepsy, Guideline, Ketogenic",
author = "{The Charlie Foundation} and {Matthew's Friends} and {the Practice Committee of the Child Neurology Society} and Kossoff, {Eric H} and Zupec-Kania, {Beth A.} and St{\'e}phane Auvin and Ballaban-Gil, {Karen R.} and {Christina Bergqvist}, {A. G.} and Robyn Blackford and Buchhalter, {Jeffrey R.} and Caraballo, {Roberto H.} and Cross, {J. Helen} and Dahlin, {Maria G.} and Donner, {Elizabeth J.} and Orkide Guzel and Jehle, {Rana S.} and Joerg Klepper and Kang, {Hoon Chul} and Lambrechts, {Danielle A.} and Liu, {Y. M.Christiana} and Nathan, {Janak K.} and Nordli, {Douglas R.} and Pfeifer, {Heidi H.} and Rho, {Jong M.} and Scheffer, {Ingrid E.} and Suvasini Sharma and Carl Stafstrom and Thiele, {Elizabeth A.} and Zahava Turner and Vaccarezza, {Maria M.} and {van der Louw}, {Elles J.T.M.} and Pierangelo Veggiotti and Wheless, {James W.} and Wirrell, {Elaine C.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/epi4.12225",
language = "English (US)",
volume = "3",
pages = "175--192",
journal = "Epilepsia Open",
issn = "2470-9239",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

TY - JOUR

T1 - Optimal clinical management of children receiving dietary therapies for epilepsy

T2 - Updated recommendations of the International Ketogenic Diet Study Group

AU - The Charlie Foundation

AU - Matthew's Friends

AU - the Practice Committee of the Child Neurology Society

AU - Kossoff, Eric H

AU - Zupec-Kania, Beth A.

AU - Auvin, Stéphane

AU - Ballaban-Gil, Karen R.

AU - Christina Bergqvist, A. G.

AU - Blackford, Robyn

AU - Buchhalter, Jeffrey R.

AU - Caraballo, Roberto H.

AU - Cross, J. Helen

AU - Dahlin, Maria G.

AU - Donner, Elizabeth J.

AU - Guzel, Orkide

AU - Jehle, Rana S.

AU - Klepper, Joerg

AU - Kang, Hoon Chul

AU - Lambrechts, Danielle A.

AU - Liu, Y. M.Christiana

AU - Nathan, Janak K.

AU - Nordli, Douglas R.

AU - Pfeifer, Heidi H.

AU - Rho, Jong M.

AU - Scheffer, Ingrid E.

AU - Sharma, Suvasini

AU - Stafstrom, Carl

AU - Thiele, Elizabeth A.

AU - Turner, Zahava

AU - Vaccarezza, Maria M.

AU - van der Louw, Elles J.T.M.

AU - Veggiotti, Pierangelo

AU - Wheless, James W.

AU - Wirrell, Elaine C.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

AB - Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

KW - Children

KW - Diet

KW - Epilepsy

KW - Guideline

KW - Ketogenic

UR - http://www.scopus.com/inward/record.url?scp=85051776915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051776915&partnerID=8YFLogxK

U2 - 10.1002/epi4.12225

DO - 10.1002/epi4.12225

M3 - Article

VL - 3

SP - 175

EP - 192

JO - Epilepsia Open

JF - Epilepsia Open

SN - 2470-9239

IS - 2

ER -