### Abstract

In a previous analysis of ventricular arterial interaction, we represented the left ventricle as an elastic chamber which periodically increases its volume elastance to a value equal to the slope of the linear end-systolic pressure-volume relationship. Similarly, the arterial load property was represented by an effective elastance which is the slope of the arterial end-systolic pressure-stroke volume relationship. Since the maximal transfer of potential energy from one elastic chamber to another occurs when they have equal elastance, we hypothesized that the left ventricle would do maximal external work if the ventricular elastance and the effective arterial elastance were equal. We tested this hypothesis in 10 isolated canine left ventricles, ejecting into a simulated arterial impedance, by extensively altering arterial resistance and finding the optimal resistance that maximized left ventricular stroke work under various combinations of end-diastolic volume, contractility, heart rate, and arterial compliance. Each of these parameters was set at one of three levels while others were at control. The optimal resistance varied only slightly with arterial compliance, whereas it varied widely with contractility and heart rate. We thus determined that the ratio of the optimal effective arterial elastance to the given ventricular elastance remained nearly unity. This result supports the hypothesis that the left ventricle does maximal external work to the arterial load when the ventricular and arterial elastances are equalized.

Original language | English (US) |
---|---|

Pages (from-to) | 586-595 |

Number of pages | 10 |

Journal | Circulation Research |

Volume | 56 |

Issue number | 4 |

State | Published - 1985 |

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### ASJC Scopus subject areas

- Physiology
- Cardiology and Cardiovascular Medicine

### Cite this

*Circulation Research*,

*56*(4), 586-595.

**Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle.** / Sunagawa, K.; Maughan, William L; Sagawa, K.

Research output: Contribution to journal › Article

*Circulation Research*, vol. 56, no. 4, pp. 586-595.

}

TY - JOUR

T1 - Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle

AU - Sunagawa, K.

AU - Maughan, William L

AU - Sagawa, K.

PY - 1985

Y1 - 1985

N2 - In a previous analysis of ventricular arterial interaction, we represented the left ventricle as an elastic chamber which periodically increases its volume elastance to a value equal to the slope of the linear end-systolic pressure-volume relationship. Similarly, the arterial load property was represented by an effective elastance which is the slope of the arterial end-systolic pressure-stroke volume relationship. Since the maximal transfer of potential energy from one elastic chamber to another occurs when they have equal elastance, we hypothesized that the left ventricle would do maximal external work if the ventricular elastance and the effective arterial elastance were equal. We tested this hypothesis in 10 isolated canine left ventricles, ejecting into a simulated arterial impedance, by extensively altering arterial resistance and finding the optimal resistance that maximized left ventricular stroke work under various combinations of end-diastolic volume, contractility, heart rate, and arterial compliance. Each of these parameters was set at one of three levels while others were at control. The optimal resistance varied only slightly with arterial compliance, whereas it varied widely with contractility and heart rate. We thus determined that the ratio of the optimal effective arterial elastance to the given ventricular elastance remained nearly unity. This result supports the hypothesis that the left ventricle does maximal external work to the arterial load when the ventricular and arterial elastances are equalized.

AB - In a previous analysis of ventricular arterial interaction, we represented the left ventricle as an elastic chamber which periodically increases its volume elastance to a value equal to the slope of the linear end-systolic pressure-volume relationship. Similarly, the arterial load property was represented by an effective elastance which is the slope of the arterial end-systolic pressure-stroke volume relationship. Since the maximal transfer of potential energy from one elastic chamber to another occurs when they have equal elastance, we hypothesized that the left ventricle would do maximal external work if the ventricular elastance and the effective arterial elastance were equal. We tested this hypothesis in 10 isolated canine left ventricles, ejecting into a simulated arterial impedance, by extensively altering arterial resistance and finding the optimal resistance that maximized left ventricular stroke work under various combinations of end-diastolic volume, contractility, heart rate, and arterial compliance. Each of these parameters was set at one of three levels while others were at control. The optimal resistance varied only slightly with arterial compliance, whereas it varied widely with contractility and heart rate. We thus determined that the ratio of the optimal effective arterial elastance to the given ventricular elastance remained nearly unity. This result supports the hypothesis that the left ventricle does maximal external work to the arterial load when the ventricular and arterial elastances are equalized.

UR - http://www.scopus.com/inward/record.url?scp=0021993531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021993531&partnerID=8YFLogxK

M3 - Article

C2 - 3978773

AN - SCOPUS:0021993531

VL - 56

SP - 586

EP - 595

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 4

ER -