Optical sensors to gain mechanistic insights into signaling assemblies

Brian Tenner, Sohum Mehta, Jin Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Protein complexes play a major role in transducing information from outside the cell into instructions for growth and survival, and understanding how these complexes relay and shape intracellular signals has been a central question in signaling biology. Fluorescent proteins have proven paramount in opening windows for researchers to peer into the architecture and inner workings of signaling assemblies within the living cell and in real-time. In this review, we will provide readers with a current perspective on the development and use of genetically encoded optical probes to dissect the function of signaling complexes.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume41
DOIs
StatePublished - Dec 1 2016

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Optical sensors to gain mechanistic insights into signaling assemblies'. Together they form a unique fingerprint.

Cite this