Optical recordings of action potential of frog ventricle during cathodal and anodal stimulation

Leslie Tung, Michel Neunlist, Sha zhou Zou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An optical fiber-based probe was developed which was coupled to a custom designed, portable fluorimeter for use with hearts stained with a voltage-sensitive fluorescent dye. Optical action potentials of frog hearts were measured in the surface layer directly underlying the stimulating electrode for cathodal and anodal square wave excitation. Both cathodal and anodal pulses were capable of eliciting action potentials and appear to activate depolarizing membrane currents. Results suggest that membrane biophysical models in a syncytial structure will be required for understanding cardiac membrane responses to field stimulation.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages603-604
Number of pages2
Editionpt 2
ISBN (Print)0780302168
StatePublished - Dec 1 1991
Externally publishedYes
EventProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, FL, USA
Duration: Oct 31 1991Nov 3 1991

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 2
Volume13
ISSN (Print)0589-1019

Other

OtherProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityOrlando, FL, USA
Period10/31/9111/3/91

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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