Optical feedback-controlled scleral remodeling as a mechanism for myopic eye growth

Michael R. Bryant, Peter J McDonnell

Research output: Contribution to journalArticle

Abstract

Experimental studies of myopia have demonstrated that optical errors imposed on a developing eye will stimulate elongation of the globe, although the mechanism of axial growth is not well understood. In this study, a mathematical model of eye growth is presented in which expansion of the globe occurs as the elastic deformations of the scleral shell are incorporated into the zero stress configuration of the eye during the scleral remodeling process. The rate of remodeling is determined by the retinal blur and the amplitude of accommodation, which provide feedback loops for both unilateral acid bilateral hyperopic refractive error-compensation. Normal eye growth and experimental myopia are simulated in tree shrews, a small mammal related to primates. The model demonstrates that the rate of ocular elongation in experimental myopia may be controlled by regulating the rate of soft tissue remodeling in the scleral shell.

Original languageEnglish (US)
Pages (from-to)613-622
Number of pages10
JournalJournal of Theoretical Biology
Volume193
Issue number4
DOIs
StatePublished - Aug 21 1998
Externally publishedYes

Fingerprint

Optical Feedback
Optical feedback
Remodeling
Globe
eyes
Elongation
Myopia
Shell
Growth
Error Compensation
Error compensation
Mammals
Elastic Deformation
Soft Tissue
Elastic deformation
Feedback Loop
Scandentia
Tupaiidae
Experimental Study
Refractive Errors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Optical feedback-controlled scleral remodeling as a mechanism for myopic eye growth. / Bryant, Michael R.; McDonnell, Peter J.

In: Journal of Theoretical Biology, Vol. 193, No. 4, 21.08.1998, p. 613-622.

Research output: Contribution to journalArticle

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