TY - JOUR
T1 - Optical coherence tomography of the optic nerve head detects acute changes in intracranial pressure
AU - Anand, Aashish
AU - Pass, Anastas
AU - Urfy, Mian Z.
AU - Tang, Rosa
AU - Cajavilca, Christian
AU - Calvillo, Eusebia
AU - Suarez, Jose I.
AU - Venkatasubba Rao, Chethan P.
AU - Bershad, Eric M.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - We aimed to determine if there are measurable objective changes in the optic nerve head (ONH) immediately after cerebrospinal fluid (CSF) drainage in a prospective case-series of five patients undergoing a clinically indicated lumbar puncture (LP) for diagnosis of idiopathic intracranial hypertension. A Cirrus high-definition optical coherence tomography machine (Carl Zeiss Meditec, Dublin, CA, USA) was used to acquire images in the lateral decubitus position. Optic disc cube and high-definition line raster scans centered on the ONH were obtained immediately before and after draining CSF, while the patient maintained the lateral decubitus position. Measured parameters included retinal nerve fiber layer (RNFL) thickness, peripapillary retinal pigment epithelium/Bruch's membrane (RPE/BM) angulation, transverse neural canal diameter (NCD) and the highest vertical point of the internal limiting membrane from the transverse diameter (papillary height). The mean (±standard deviation) opening and closing CSF pressures were 34.3 ± 11.8 and 11.6 ± 3.3 cmH2O, respectively. Mean RNFL thickness (pre LP: 196 ± 105 μm; post LP: 164 ± 77 μm, p = 0.1) and transverse NCD (pre LP: 1985 ± 559 μm; post LP: 1590 ± 228 μm, p = 2.0) decreased in all subjects, but with non-significant trends. The RPE/BM angle (mean change: 5.8 ± 2.0 degrees, p = 0.003) decreased in all subjects. A decrease in papillary height was seen in three of five subjects (mean: pre LP: 976 ± 275 μm; post LP: 938 ± 300 μm, p = 0.9). Our results show a measurable, objective change in the ONH after acute lowering of the lumbar CSF pressure, suggesting a direct link between the lumbar subarachnoid space and ONH regions, and its potential as a non-invasive method for monitoring intracranial pressures.
AB - We aimed to determine if there are measurable objective changes in the optic nerve head (ONH) immediately after cerebrospinal fluid (CSF) drainage in a prospective case-series of five patients undergoing a clinically indicated lumbar puncture (LP) for diagnosis of idiopathic intracranial hypertension. A Cirrus high-definition optical coherence tomography machine (Carl Zeiss Meditec, Dublin, CA, USA) was used to acquire images in the lateral decubitus position. Optic disc cube and high-definition line raster scans centered on the ONH were obtained immediately before and after draining CSF, while the patient maintained the lateral decubitus position. Measured parameters included retinal nerve fiber layer (RNFL) thickness, peripapillary retinal pigment epithelium/Bruch's membrane (RPE/BM) angulation, transverse neural canal diameter (NCD) and the highest vertical point of the internal limiting membrane from the transverse diameter (papillary height). The mean (±standard deviation) opening and closing CSF pressures were 34.3 ± 11.8 and 11.6 ± 3.3 cmH2O, respectively. Mean RNFL thickness (pre LP: 196 ± 105 μm; post LP: 164 ± 77 μm, p = 0.1) and transverse NCD (pre LP: 1985 ± 559 μm; post LP: 1590 ± 228 μm, p = 2.0) decreased in all subjects, but with non-significant trends. The RPE/BM angle (mean change: 5.8 ± 2.0 degrees, p = 0.003) decreased in all subjects. A decrease in papillary height was seen in three of five subjects (mean: pre LP: 976 ± 275 μm; post LP: 938 ± 300 μm, p = 0.9). Our results show a measurable, objective change in the ONH after acute lowering of the lumbar CSF pressure, suggesting a direct link between the lumbar subarachnoid space and ONH regions, and its potential as a non-invasive method for monitoring intracranial pressures.
KW - Idiopathic intracranial hypertension
KW - Intracranial pressure
KW - Optic nerve
KW - Optical coherence tomography
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U2 - 10.1016/j.jocn.2015.12.016
DO - 10.1016/j.jocn.2015.12.016
M3 - Article
C2 - 26898579
AN - SCOPUS:84958582092
VL - 29
SP - 73
EP - 76
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
ER -