Optical coherence tomography findings in endogenous fungal chorioretinitis, retinitis, and endophthalmitis

John D. Stephens; Murtaza K. Adam; Bohzo Todorich; Lisa J. Faia; Sunir Garg; James P. Dunn; Sonia Mehta

doi:10.3928/23258160-20171030-04

Optical coherence tomography findings in endogenous fungal chorioretinitis, retinitis, and endophthalmitis

John D. Stephens, Murtaza K. Adam, Bohzo Todorich, Lisa J. Faia, Sunir Garg, James P. Dunn, Sonia Mehta

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement. Six of 12 eyes had follow-up imaging performed after antifungal treatment, which demonstrated decreased size of choroidal and/or retinal infiltrates. CONCLUSIONS: All patients with follow-up imaging had anatomic improvement by OCT of the lesions with treatment. In the future, OCT imaging may provide a method to assess therapeutic response and prognosis for visual recovery in patients with endogenous fungal ocular disease.

Original language	English (US)
Pages (from-to)	894-901
Number of pages	8
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	48
Issue number	11
DOIs	https://doi.org/10.3928/23258160-20171030-04
State	Published - Nov 2017

ASJC Scopus subject areas

Surgery
Ophthalmology

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10.3928/23258160-20171030-04

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@article{64760588103e4e17a402679f5b8c8969,

title = "Optical coherence tomography findings in endogenous fungal chorioretinitis, retinitis, and endophthalmitis",

abstract = "BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement. Six of 12 eyes had follow-up imaging performed after antifungal treatment, which demonstrated decreased size of choroidal and/or retinal infiltrates. CONCLUSIONS: All patients with follow-up imaging had anatomic improvement by OCT of the lesions with treatment. In the future, OCT imaging may provide a method to assess therapeutic response and prognosis for visual recovery in patients with endogenous fungal ocular disease.",

author = "Stephens, {John D.} and Adam, {Murtaza K.} and Bohzo Todorich and Faia, {Lisa J.} and Sunir Garg and Dunn, {James P.} and Sonia Mehta",

note = "Funding Information: Originally submitted February 14, 2017. Revision received May 17, 2017. Accepted for publication June 2, 2017. This study was supported by a grant from the Heed Ophthalmic Foundation (MKA). The supporting source had no involvement in study design, collection, analysis and interpretation of data, writing the report, or the decision to submit the report for publication. Dr. Garg has received personal fees from Deciphera, Allergan, Bausch + Lomb, and Santen; grants and personal fees from Genentech; and grants from Regeneron, Eyegate, Centocor, and Johnson & Johnson outside the submitted work. Dr. Dunn is on the speakers bureau for AbbVie. The remaining authors report no relevant financial disclosures. Address correspondence to Sonia Mehta, MD, Wills Eye Hospital, 840 Walnut St., Suite 1020, Philadelphia, PA 19107; email: smehta@midatlanticretina.com. doi: 10.3928/23258160-20171030-04 Publisher Copyright: {\textcopyright} 2017, Slack Incorporated. All rights reserved.",

year = "2017",

month = nov,

doi = "10.3928/23258160-20171030-04",

language = "English (US)",

volume = "48",

pages = "894--901",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

issn = "2325-8160",

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number = "11",

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T1 - Optical coherence tomography findings in endogenous fungal chorioretinitis, retinitis, and endophthalmitis

AU - Stephens, John D.

AU - Adam, Murtaza K.

AU - Todorich, Bohzo

AU - Faia, Lisa J.

AU - Garg, Sunir

AU - Dunn, James P.

AU - Mehta, Sonia

N1 - Funding Information: Originally submitted February 14, 2017. Revision received May 17, 2017. Accepted for publication June 2, 2017. This study was supported by a grant from the Heed Ophthalmic Foundation (MKA). The supporting source had no involvement in study design, collection, analysis and interpretation of data, writing the report, or the decision to submit the report for publication. Dr. Garg has received personal fees from Deciphera, Allergan, Bausch + Lomb, and Santen; grants and personal fees from Genentech; and grants from Regeneron, Eyegate, Centocor, and Johnson & Johnson outside the submitted work. Dr. Dunn is on the speakers bureau for AbbVie. The remaining authors report no relevant financial disclosures. Address correspondence to Sonia Mehta, MD, Wills Eye Hospital, 840 Walnut St., Suite 1020, Philadelphia, PA 19107; email: smehta@midatlanticretina.com. doi: 10.3928/23258160-20171030-04 Publisher Copyright: © 2017, Slack Incorporated. All rights reserved.

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement. Six of 12 eyes had follow-up imaging performed after antifungal treatment, which demonstrated decreased size of choroidal and/or retinal infiltrates. CONCLUSIONS: All patients with follow-up imaging had anatomic improvement by OCT of the lesions with treatment. In the future, OCT imaging may provide a method to assess therapeutic response and prognosis for visual recovery in patients with endogenous fungal ocular disease.

AB - BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement. Six of 12 eyes had follow-up imaging performed after antifungal treatment, which demonstrated decreased size of choroidal and/or retinal infiltrates. CONCLUSIONS: All patients with follow-up imaging had anatomic improvement by OCT of the lesions with treatment. In the future, OCT imaging may provide a method to assess therapeutic response and prognosis for visual recovery in patients with endogenous fungal ocular disease.

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JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

IS - 11

ER -

Optical coherence tomography findings in endogenous fungal chorioretinitis, retinitis, and endophthalmitis

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