Abstract
Background and purpose: In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) - with its potential to reveal neuroaxonal retinal damage - may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. Methods: Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised. Results: There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity. Conclusions: These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS.
Original language | English (US) |
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Pages (from-to) | 1170-1176 |
Number of pages | 7 |
Journal | European Journal of Neurology |
Volume | 20 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- Amyotrophic lateral sclerosis
- Multisystem disorder
- Optical coherence tomography
- Retina
ASJC Scopus subject areas
- Neurology
- Clinical Neurology